New methods for the synthesis of 2-(2,2,2-trichloroethoxy)-(3,4,6-tri-O-acetyl-1,2-dideoxy-α-D-glucopyrano)-[2,1-d]-2-oxazoline and its use for stereo-, chemo- and regioselective glycosylation.

New methods for the synthesis of the title oxazoline 2 from the corresponding 2-deoxy-2-(2,2,2- trichloroethoxycarbonylamino)glucosyl bromide were developed. The target 2-(2,2,2-trichloroethoxy) gluco-[2,1-d]-2-oxazoline 2 can be synthesized under conditions of halide ion catalysis, using triethylamine as a base. The synthesized 2-(2,2,2-trichloroethoxy)-2-oxazoline glycosyl donor was used for stereo-, regio-, and chemoselective glycosylation reactions under extremely mild conditions.

The study of the acid-catalyzed reaction between 2-methyl and 2-(2,2,2-trichloroethoxy) gluco-[2,1-d]-2-oxazolines. Synthesis of macrocyclic pseudo-tetrasaccharide derivative of d-glucosamine.

The formation of macrocyclic pseudo-tetrasaccharide derivative of d-glucosamine as a result of the acid-catalyzed reaction between 2-methyl- and 2-(2,2,2-trichloroethoxy)-substituted oxazoline derivatives of sugars was discovered. The structure of the obtained product was determined using NMR spectroscopy and mass spectrometry. An explanation of the obtained results based on the mechanism of the reaction of electrophilic polymerization of 2-substituted glyco-[2,1-d]-2-oxazolines and the principle of hard and soft acids and bases (HSAB) was proposed.

[A cytomorphological basis for the correction of radiation-induced immunodeficiencies and hematopoietic depression using thymus and bone marrow peptides].

The correction of radiation-induced immunodeficiency and hematopoiesis depression in clinical setting (100 patients) and in experiments (160 animals) by peptide preparations of the thymus and bone marrow (thymalin, hemalin, thymogemine and synthetic thymalin analog thymogen) has been studied. Administration of the bone marrow and thymus recovery of damage to the thymus, bone marrow, spleen and lymph nodes, improved the function of circulating neutrophilic granulocytes. Thymalin was able to compensate for immune disturbances and reduce manifestations of asthenia.

[The clinico-epidemiological efficacy of thymogen in acute respiratory viral infections in a military collective].

This study gathers the results of epidemiological examination in training military unit, making evaluation of prophylactic efficiency of timogen, i.e. synthetic peptide of thymus for flu and other acute respiratory infections (ARI).

[Thymogen in the complex treatment of inflammatory diseases of the female genital system].

Thymogen, a new immunomodulating drug made in this country, was used in combined therapy of 46 patients with acute endomyometritis, exacerbations of chronic salpingo-oophoritis, purulent tubo-ovarian formations. Thymogen therapy was conducive to normalization of lymphocyte counts, absolute counts of T and B lymphocytes, increase of T lymphocyte functional activity. The drug is characterized by a desensitizing effect and induces no complications.