Activity of sphingomyelinase in rat liver in acute and chronic toxic hepatitis: proportion between peroxidative and phospholipase pathways of lipid bilayer modification.

We showed that sphingomyelinase activity in the liver increased only during the acute phase of toxic hepatitis. Peroxidative modification of hepatocyte membrane bilayer prevailed during the acute phase, while after transformation of the process to the chronic phase phospholipase pathway predominated.

Functional activity of sphingomyelin cycle in rat liver in chronic toxic hepatitis.

Activities of sphingomyelinase and ceramidase decreased in the liver in chronic toxic hepatitis and the balance between the levels of proapoptotic ceramide and antiapoptotic sphyngosine-1-phosphate shifts towards the latter substance. Pronounced changes in the qualitative and quantitative composition of fatty acids in the sphingomyelin cycle effector molecules were revealed.

Validity of a new portable indirect calorimeter: the AeroSport TEEM 100.

The purpose of this study was to compare oxygen uptake (VO2) values collected with a new portable indirect calorimeter (AeroSport TEEM 100 Metabolic Analysis System) against a more traditional large calorimeter system that has been reported to be valid and reliable (SensorMedics 2900 Metabolic Measurement Cart). Minute ventilations ranging from rest up to heavy exercise were compared with simultaneous measurements from a 120-1 Tissot gasometer. Each of the three TEEM 100 pneumotachs were tested.

Cytokines in sleep regulation.

The central thesis of this essay is that the cytokine network in brain is a key element in the humoral regulation of sleep responses to infection and in the physiological regulation of sleep. We hypothesize that many cytokines, their cellular receptors, soluble receptors, and endogenous antagonists are involved in physiological sleep regulation. The expressions of some cytokines are greatly amplified by microbial challenge.