Publications by authors named "S V Nikolaev"
Assessments of breast cancer (BC) risk in carriers of pathogenic variants identified by gene panel testing in different populations are highly in demand worldwide. We performed target sequencing of 78 genes involved in DNA repair in 860 females with BC and 520 age- and family history-matched controls from Central Russia. Among BC patients, 562/860 (65.
View Article and Find Full Text PDFThe accumulated evidence suggests that varying levels of tyrosine kinase receptor signaling pathway activity may regulate opiate-associated neuroadaptation of noradrenergic system. Neurotrophin-3 (NT-3) interacts with tropomyosin receptor kinases (TRKs), binding mainly to TRKC receptors, which are expressed within noradrenergic neurons in the blue spot (, LC). Considering the difficulties in delivering full-length neurotrophins to the CNS after systemic administration, low-molecular mimetics of loop 4 in NT-3, hexamethylenediamide bis-(N-monosuccinyl-L-asparaginyl-L-asparagine) (GTS-301), and hexamethylenediamide bis-(N-γ-oxybutyryl-L-glutamyl-L-asparagine) (GTS-302), activating TRKC and TRKB receptors, were synthesized.
View Article and Find Full Text PDFArticle Synopsis
- Recent experiments demonstrated a significant increase in torques when a thin aluminum layer was added to a cobalt/platinum heterostructure, indicating a possible Rashba-like interaction at the Co/Al interface.
- First-principles calculations revealed that this interaction leads to the emergence of a large helical orbital texture in the cobalt layer, driven by the orbital Rashba effect and the formation of surface states at the interface.
- The study highlights that this orbital texture results in a nonequilibrium orbital accumulation, producing large current-induced torques and providing a theoretical foundation for using orbital transport phenomena in all-metallic magnetic systems with lighter elements.
Article Synopsis
- - The MATCH-R trial aimed to analyze the resistance mechanisms to cancer treatments by studying fresh tumor biopsies from metastatic patients, covering data collected from 2015 to 2022.
- - Out of 1,120 biopsies from patients primarily with lung, digestive, and prostate cancers, 30.9% revealed targetable genomic alterations, with EGFR being the most common altered gene.
- - Among patients with resistance mechanisms, 45% had treatments tailored based on identified mechanisms, resulting in an average of 11 months of additional clinical benefit.
Article Synopsis
- The Letter reports the most accurate measurement so far of the matter-antimatter imbalance during Pb-Pb collisions at a high energy level of 5.02 TeV.
- It utilizes the Statistical Hadronization framework to determine precise values for the electric charge and baryon chemical potentials, μ_{Q} and μ_{B}.
- The analysis of antiparticle-to-particle yield ratios shows that the collisions create a system that is generally baryon-free and electrically neutral at midrapidity.