[Towards the estimation of survival curves parameters and geroprotectors classification].

The following parameters are proposed to estimate in survival curves analysis: Median Life Span, Hill slope, Expected Maximal Life Span. Those estimates enable to classify geroprotectors as weak, moderate and strong.

[Consequences of selection in highly inbred Drosophila strains].

The results of three long-term breeding and genetic experiments with Drosophila melanogaster performed at different times are summarized. Selections for different fitness components led to similar results. The data on the concentration of viability mutations in the inbred strains LA, LA+, and LA- after 400 generations of selection and the strain ULA during its breeding are presented for the first time.

Effects of peptides on generation of reactive oxygen species in subcellular fractions of Drosophila melanogaster.

We studied the effects of Epithalon (Ala-Glu-Asp-Gly) and Vilon (Lys-Glu) on free radical processes in highly inbred HA(+)line of Drosophila melanogaster. Vilon inhibited generation of reactive oxygen species in mitochondria, but stimulated this process in the cytosol. We found sex- and age-related differences in the generation of reactive oxygen species and cytosol antioxidant activity.

Effect of epithalone on the age-specific changes in the time course of lipid peroxidation in Drosophila melanogaster.

The effect of epithalone on the age-specific time course of lipid peroxidation was studied in inadaptive Drosophila melanogaster strains. A single dose of epithalone at the larval stage decreased the level of conjugated hydroperoxides and Schiff bases throughout the life span of imago. Strain- and sex-specific differences in the time course of the studied sign are characterized.