6-Aryl- and 6,7-diaryl-1,3-dimethyl-1-perimidin-2(3)-ones: synthesis, conformational stability, crystal structure and optical properties.

6-Bromo- and 6,7-dibromo-1,3-dimethyl-1-perimidin-2(3)-ones were arylated with arylboronic acids under Suzuki-Miyaura reaction conditions to afford 6-aryl-, 6-bromo-7-aryl- and 6,7-diaryl-1,3-dimethyl-1-perimidin-2(3)-ones. A comparison of the X-ray structural parameters of -diaryl derivatives of 1,3-dimethyl-1-perimidin-2(3)-one, naphthalene and 1,8-bis(dimethylamino)naphthalene (proton sponge) was performed. Based on the data of dynamic H NMR spectroscopy and quantum-chemical calculations, barriers to /-isomerization of 6,7-diaryl-1,3-dimethyl-1-perimidin-2(3)-ones were estimated.

Individualized selection of recent glucose monitoring devices for self-management based on competitive features.

Objective: Goal of the study was to systematically review competitive advantages of medical devices for glucose monitoring in diabetic patients.

Method: The review is done systematically according to SALSA criteria and PRISMA guidelines. The search for eligible articles was held from February 16 2023 to March 1 2023 in Russian and English languages.

[Comparative characteristics of the efficacy and safety of the original alteplase and its complete biosimilar in the treatment of ischemic stroke in real clinical practice].

Objective: To conduct a comparative analysis between the original alteplase and its biosimilar in terms of efficacy and safety in real clinical practice in the Republic of Belarus.

Material And Methods: The cohort study included 420 patients. All included patients underwent thrombolytic therapy with alteplase within 4.

AHRR and SFRP2 in primary versus recurrent high-grade serous ovarian carcinoma and their prognostic implication.

Background: The aim of this study was to analyse transcriptomic differences between primary and recurrent high-grade serous ovarian carcinoma (HGSOC) to identify prognostic biomarkers.

Methods: We analysed 19 paired primary and recurrent HGSOC samples using targeted RNA sequencing. We selected the best candidates using in silico survival and pathway analysis and validated the biomarkers using immunohistochemistry on a cohort of 44 paired samples, an additional cohort of 504 primary HGSOCs and explored their function.

Validation of the time to attain maximal clot amplitude after reaching maximal clot formation velocity parameter as a measure of fibrinolysis using rotational thromboelastometry and its application in the assessment of fibrinolytic resistance in septic patients: a prospective observational study: communication from the ISTH SSC Subcommittee on Fibrinolysis.

Background: In sepsis, fibrinolysis resistance correlates with worse outcomes. Practically, rotational thromboelastometry (ROTEM) is used to report residual clot amplitude relative to maximum amplitude at specified times after clot formation clot lysis indices (CLIs). However, healthy individuals can exhibit similar CLIs, thus making it challenging to solely diagnose the low fibrinolytic state.