Publications by authors named "S V Mallett"
Background: The clinical translation of positron emission tomography (PET) radiotracers for cancer management presents complex challenges. We have developed consensus-based recommendations for preclinical and clinical assessment of novel and established radiotracers, applied to image different cancer types, to improve the standardisation of translational methodologies and accelerate clinical implementation.
Methods: A consensus process was developed using the RAND/UCLA Appropriateness Method (RAM) to gather insights from a multidisciplinary panel of 38 key stakeholders on the appropriateness of preclinical and clinical methodologies and stakeholder engagement for PET radiotracer translation.
Article Synopsis
- - The ROCkeTS study aimed to find the best diagnostic test for ovarian cancer in symptomatic postmenopausal women by comparing multiple risk-prediction models in a real-world setting.
- - Researchers recruited women aged 16-90 with non-specific symptoms and abnormal test results from 23 UK hospitals, excluding those with certain conditions like normal CA125 levels or other cancers.
- - The study involved various diagnostic models and tests, including CA125 levels and ultrasound assessments, to evaluate their effectiveness in predicting ovarian cancer risk among the participants.
Objective: Symptom-triggered testing for ovarian cancer was introduced to the UK whereby symptomatic women undergo an ultrasound scan and serum CA125, and are referred to hospital within 2 weeks if these are abnormal. The potential value of symptom-triggered testing in the detection of early-stage disease or low tumor burden remains unclear in women with high grade serous ovarian cancer. In this descriptive study, we report on the International Federation of Gynecology and Obstetrics (FIGO) stage, disease distribution, and complete cytoreduction rates in women presenting via the fast-track pathway and who were diagnosed with high grade serous ovarian cancer.
View Article and Find Full Text PDFAn assessment of the validity of studies is an essential component of most evidence syntheses (systematic reviews) to understand the risk of bias (ROB) and applicability of the evidence. A formal validity assessment requires a structured and comprehensive approach, which can be implemented using an assessment tool, specifically developed for this purpose. Many different tools are available, marking it difficult for researchers to choose the best tool for their evidence synthesis.
View Article and Find Full Text PDFObjectives: Magnetic resonance enterography (MRE) interpretation of Crohn's disease (CD) is subjective and uses 2D analysis. We evaluated the feasibility of volumetric measurement of terminal ileal CD on MRE compared to endoscopy and sMARIA, and the responsiveness of volumetric changes to biologics.
Methods: CD patients with MRE and contemporaneous CD endoscopic index of severity-scored ileocolonoscopy were included.