Dual-energy three-compartment breast imaging for compositional biomarkers to improve detection of malignant lesions.

Background: While breast imaging such as full-field digital mammography and digital breast tomosynthesis have helped to reduced breast cancer mortality, issues with low specificity exist resulting in unnecessary biopsies. The fundamental information used in diagnostic decisions are primarily based in lesion morphology. We explore a dual-energy compositional breast imaging technique known as three-compartment breast (3CB) to show how the addition of compositional information improves malignancy detection.

Mammary collagen architecture and its association with mammographic density and lesion severity among women undergoing image-guided breast biopsy.

Background: Elevated mammographic breast density is a strong breast cancer risk factor with poorly understood etiology. Increased deposition of collagen, one of the main fibrous proteins present in breast stroma, has been associated with increased mammographic density. Collagen fiber architecture has been linked to poor outcomes in breast cancer.

Entropy-driven translocation of disordered proteins through the Gram-positive bacterial cell wall.

In Gram-positive bacteria, a thick cross-linked cell wall separates the membrane from the extracellular space. Some surface-exposed proteins, such as the Listeria monocytogenes actin nucleation-promoting factor ActA, remain associated with the bacterial membrane but somehow thread through tens of nanometres of cell wall to expose their amino terminus to the exterior. Here, we report that entropy enables the translocation of disordered transmembrane proteins through the Gram-positive cell wall.

Evolution of stability of socioeconomic system functioning: Some approaches to modeling (with an application to the case of Egypt, 2011-2013).

This paper proposes a methodological approach to analyzing the evolution of the stability of socioeconomic systems and to assessing the risk of their possible destabilization based on the use of mathematical modeling methods. In this paper, a basic model is presented allowing us to describe the joint dynamics of processes in the economic, organizational, and sociopsychological areas of society. The model shows at what parameters of the socioeconomic system its steady functioning is possible, and at which it is impossible.

A methodology for analyzing and forecasting sociopolitical destabilization.

The article presents a methodology for the analysis of political crises meant to assess the current situation of sociopolitical (in)stability of the developing and developed societies in question, provide an inertial forecast of the developing situation in a given period, analyse threats to stability threats, and examine possible measures to counteract such threats and their likely influence on the situation. The methodology is based on modeling sociopolitical stability in the country in question with the help of an elaborate logical-mathematical model.