[FEATURES OF PREOPERATIVE PREPARATION OF PATIENTS WITH DIFFERENT FORMS OF CLINICAL COURSE OF PHEOCHROMOCYTOMA].

A comparative analysis of subjective and objective criterion was made in order to evaluate efficacy of preoperative preparation in 101 patients with pheochromocytoma of different clinical course. It was shown the reasonability of monitoring usage of noninvasive method of assessment of systemic hemodynamics (bio-impedance reo-vasography and daily monitoring of arterial pressure) for evaluation of preoperative preparation adequacy. The need of differentiated approach and strategy of preoperative preparation were based on clinical course of pheochromocytoma.

[THE MECHANISMS OF ACTION OF RITUXIMAB].

Rituximab is a chimeric monoclonal antibody containing constant kappa-regions of the Fc fragment of IgGI human immunoglobulin and variable fragments of IgG murine immunoglobulin. This modified immunoglobulin structure makes rituximab capable of specifically recognizing CD20 antigen that is mainly expressed on B-lymphocytes. The review considers four main mechanisms of rituximab action leading to reduction of the population of B-lymphocytes in patients with lymphoproliferative processes.