ST-elevation myocardial infarction, pulmonary embolism, and cerebral ischemic stroke in a patient with critically low levels of natural anticoagulants.

This clinical case report describes the simultaneous development of an acute myocardial infarction, stroke, and a massive pulmonary thromboembolism in a 44-year-old patient - a carrier of the thrombophilia gene polymorphisms: MTHFR C677T, А1298C, PAI-1 4G/5G, ITGA2 C807T. Multifocal thrombosis was probably due to the initial congenital deficiency of anticoagulants, accompanied by a decrease in antithrombin III and protein C, against the background of their critical consumption in cascade thrombosis, in combination with the carrier of polymorphisms of moderate and low thrombogenic risk. This case is unique in that there is usually a tendency toward clinical thrombosis when the level of antithrombin III is less than 70%.

[Hairy-cell leukemia (a review of the literature and the authors' own data)].

Gene engineering interferon made in Russia (reaferon, realdiron) was given to 40 patients with hairy-cell leukemia. Complete and partial remissions were achieved in 56% and 28% of the patients, respectively. Minimum effect was reported in 3% of the cases.

[The proliferative activity of myelokaryocytes and the cellular composition of the bone marrow].

Flow cytometry was used to study myelokaryocyte distribution according to the stage of the cellular cycle in 167 bone marrow specimens 94 of which were taken by puncture from hemoblastosis and anemia patients. The results obtained were compared with myelogram data. It has been established that the method provides stable and reliable values, irrespective of cellular composition of the puncture specimens.