Exploring the anti‑inflammatory activity of boron compounds through the miR‑21/PTEN/AKT pathway in cecal ligation and puncture‑induced sepsis.

The present study investigated the impact of boric acid (BA) and borax (BX) on markers of inflammation and modifications in miR‑21/PTEN/AKT pathway genes in the liver and kidney tissues of Sprague Dawley male rats with sepsis induced by cecal ligation and puncture (CLP). A total of 60 male Sprague Dawley rats were randomly divided into 6 groups, each containing 10 animals as follows: Control, CLP (where the model was created), 20 mg/kg BX (CLP + BX1), 40 mg/kg BX (CLP + BX2), 20 mg/kg BA (CLP + BA1) and 40 mg/kg BA (CLP + BA2). Liver and kidney tissues were analyzed for histopathological changes, immunopositivity for tumor necrosis factor‑α, interleukin (IL)‑6 and IL‑10, and gene expression of microRNA‑21 (miR‑21), phosphatase and tensin homolog (PTEN) and AKT.

Weighted Attribute-Based Proxy Re-Encryption Scheme with Distributed Multi-Authority Attributes.

Existing attribute-based proxy re-encryption schemes suffer from issues like complex access policies, large ciphertext storage space consumption, and an excessive authority of the authorization center, leading to weak security and controllability of data sharing in cloud storage. This study proposes a Weighted Attribute Authority Multi-Authority Proxy Re-Encryption (WAMA-PRE) scheme that introduces attribute weights to elevate the expression of access policies from binary to multi-valued, simplifying policies and reducing ciphertext storage space. Simultaneously, the multiple attribute authorities and the authorization center construct a joint key, reducing reliance on a single authorization center.

Toxic Kidney Damage in Rats Following Subchronic Intraperitoneal Exposure to Element Oxide Nanoparticles.

Chronic diseases of the urogenital tract, such as bladder cancer, prostate cancer, reproductive disorders, and nephropathies, can develop under the effects of chemical hazards in the working environment. In this respect, nanosized particles generated as by-products in many industrial processes seem to be particularly dangerous to organs such as the testes and the kidneys. Nephrotoxicity of element oxide particles has been studied in animal experiments with repeated intraperitoneal injections of AlO, TiO, SiO, PbO, CdO, CuO, and SeO nanoparticles (NPs) in total doses ranging from 4.

[Cow colostrum: component composition, biological properties and application practice].

Bovine colostrum (ВС) has a high biological value, which allows it to be used for the development of new functional products. of the study was to assess the possibility of using BC for the prevention and treatment of infectious and non-infectious diseases. .

Supermolecular Nanoentities of Vitamin B Derivative as a Link in the Evolution of the Parent Molecules During Self-Assembly at the Air-Water Interface.

Nanoarchitectures with promising properties have now been formed from many important biomolecules. However, the preparation of nanoparticles of vitamin B and its derivatives remains an ongoing research challenge. This paper describes the formation of supermolecular nanoentities (SMEs) of vitamin B derivatives, unique nanoparticles with strong noncovalent intermolecular interactions, emerging properties, and activity.