Publications by authors named "S V Koryakin"
Article Synopsis
- Kidney disease is becoming a major global health concern, with projections indicating it will rank as the fifth-leading cause of life lost by 2040.
- The research focuses on understanding the dose-dependent effects of electron irradiation on renal tissue, as the impact of this type of radiation is not well studied compared to others like gamma and X-rays.
- Findings show that higher doses of electron irradiation cause increased oxidative stress, inflammation, and significant damage to kidney tissue, including apoptosis and early fibrosis, highlighting the importance of managing radiation doses to protect kidney function.
Combined proton-neutron therapy can be the best opportunity for neutron radiation therapy due to highly conformal proton irradiation and high relative biological effectiveness of neutrons. The study compares 4 schemes of sequential in vitro exposure of Chinese hamster fibrosarcoma cells B14-150 to 14.5 MeV neutrons and a scanning beam of protons.
View Article and Find Full Text PDFArticle Synopsis
- - Radiation-induced liver disease (RILD) is a serious side effect of radiotherapy used for abdominal cancers, particularly affecting the liver's crucial functions and limiting the overall effectiveness of treatment.
- - Electron beam therapy has shown promise in targeting tumors with less damage to surrounding healthy tissue, but the long-term effects on liver health and the potential for chronic damage need further research, especially regarding vitamin C's protective qualities.
- - A study involving male Wistar rats examined the impact of electron beam radiation and vitamin C on liver health, showing that radiation caused weight loss and liver mass reduction, while various biochemical and genetic analyses provided insights into how vitamin C might mitigate some of these adverse effects.
Aim: To access efficacy and safety of the upright proton therapy for the skull-base chordomas and chondrosarcomas.
Materials And Methods: The study encompasses single-center experience of proton therapy in chordomas (CA) and chondrosarcomas (CSA) of skull-base localization. We evaluate overall survival, local control and toxicity.
Proton therapy can treat tumors located in radiation-sensitive tissues. This article demonstrates the possibility of enhancing the proton therapy with targeted gold nanoparticles that selectively recognize tumor cells. Au-PEG nanoparticles at concentrations above 25 mg/L and 4 Gy proton dose caused complete death of EMT6/P cells in vitro.
View Article and Find Full Text PDF