[The impact of therapy with Mexidol on neurological deficit and functional outcome in patients with ischemic stroke: a systematic review and meta-analysis].

Objective: To evaluate systematically the published peer-reviewed literature and estimate the effect of therapy with Mexidol on the course and outcomes of ischemic stroke (II) in adult patients.

Material And Methods: The meta-analysis included 11 studies reported In Russian (2 randomized controlled studies, 9 non-randomized, unblinded cohort studies).

Results: The results obtained indicate a positive effect of Mexidol on the course of II in the treated adult patients: we found statistically significant decrease in NIHSS scores on days 7-10 and 21-24 and in modified Rankin scale scores on days 5-7 and days 10-14 compared with the control group.

[Epidemiology and features of statistical accounting of in-hospital ischemic stroke (St. Petersburg experience)].

Objective: To evaluate the effectiveness of the existing registration system and propose an epidemiological model for statistical accounting of the frequency of development of in-hospital ischemic stroke (IHS) in medical organizations of the Russian Federation on the example of St. Petersburg.

Material And Methods: The design of the study, conducted in the period 2014-2021, included two stages.

[Perioperative stroke in heart valve surgery: pathogenesis, clinical findings, diagnosis, prevention, treatment].

Aim: To study risk factors, characteristics of clinical symptoms and diagnosis, and possibilities of prevention of perioperative stroke and other clinical types of cerebral dysfunction in main types of heart valve surgery.

Material And Methods: The study included 83 patients, aged 63 (54; 70) years, undergoing heart valve surgery with cardiopulmonary bypass.

Results: Postoperative cerebral dysfunction was diagnosed in 37.

[Pathogenetic mechanisms of traumatic brain disease and main lines of their treatment].

To assess efficacy and tolerability of axamon (ipidacrine) in the complex therapy of patients with cranial-brain injuries, 40 patients have been studied. Patients of the main group (20 persons) received, along with traditional therapy, axamon in dose 0,02 g 3 times daily during 2 months and patients of the control group (20 persons) received only traditional therapy. Clinical examination and assessment with NIS, Autonomic Symptoms Questionnaire, Hamilton anxiety scale, electrophysiological study (magnetic diagnostics, electroneuromyography with investigation of somatosensory evoked potentials, brain CT (MRI) have been conducted at the beginning of treatment and 1 and 2 months after.