Klin Lab Diagn
April 2012
The article provides an example from clinical practice concerning the case when homozygotic beta-thalassemia was primarily diagnosed in female patient only in mature age because of lacking of manifesting clinical picture typical for this disease.
View Article and Find Full Text PDFThe paper describes a rare case of formation of paravertebral extramedullary hemopoietic foci in microspherocytic anemia or Minkovsky-Shoffar disease in an adult. Therapeutic splenectomy has led to regression of extramedullary hemopoietic foci, which supports that there is a direct relationship of the above formations to the specific features of the etiology and pathogenesis of microspherocytic anemia.
View Article and Find Full Text PDFAim: To study density-specific distribution of erythrocytes (DSDE) in different types of anemia.
Material And Methods: DSDE was determined in anemic patients by fractionation of the whole blood in hematocritic capillaries in the presence of mixtures of dimethyl- and dibutylphthalates with known density.
Results: Parameters are proposed which characterize DSDE changes typical for each type of anemia: mean erythrocyte density (MED)--mean density of total erythrocytic population; DSDE width (W)--a characteristic of erythrocytic population heterogeneity; light fraction of erythrocytes (LEF)--% of the cells with density less than 1.
Study of erythrocyte density and deformability in patients with hemolytic anemia, including long-term monitoring of 5 patients, helped us to characterize the pathological processes leading to changes in the erythrocyte population at different terms of the disease and to detect its main stages (agglutination, pathological dehydration, combination of pathological dehydration and microvesiculation, hemolytic crisis, and remission).
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