[Analysis of the antigenic properties of hemagglutinins of isolates of the influenza A virus (H1N1), isolated in 1986 in the Byelorussian SSR].

The influenza epidemic occurring in Minsk in the autumn of 1986 was caused by at least two drift variants of influenza A virus (H1N1 subtype) differing in two antigenic determinants of hemagglutinin from the viruses isolated in previous years (A/USSR/90/77, A/Dunedin/6/83). One of the epidemic drift variants was found to be identical in the antigenic properties of hemagglutinin with the reference A/Taiwan/1/86 virus.

[Immunological shifts and effectiveness of vaccination in patients with recurrent herpetic stomatitis].

The effects of herpes vaccine on immunologic parameters and clinical manifestations of recurrent herpes stomatitis (RHS) were studied. Altogether 70 patients with RHS were examined: 30 before and 40 after vaccination and revaccination. The clinical effect of vaccination was shown to be associated with stimulation of cell-mediated factors of immunity as well as with the desensitizing effect of the vaccine.

[Mechanism of virus-induced immunopathology. I. The reactivity of immunocompetent cells in acute herpetic infection in an experiment].

The state of general and specific responsiveness of thymocytes and splenocytes in non-inbred white mice has been studied in the reaction of lymphocyte blast transformation under the influence of phytohemagglutinin (PHA) and herpes simplex virus. Experimental herpetic encephalitis has been shown to give rise to the development of pronounced immunosuppression, which is confirmed by a considerable decrease (P less than 0.05) in the levels of the PHA- and virus-induced transformation of thymocytes and splenocytes in infected mice in comparison with the similar transformation characteristics of intact lymphocytes.

[Strain differences in the neuraminidase specificity of subtype N 1].

Nine strains having neuraminidase of subtype N1 and two strains in which the appurtenance of neuraminidase to subtype N1 was determined in the course of the study were examined for the antigenic specificity of the functional center of the enzyme in the cross neuraminidase activity inhibition test. Neuraminidase of the strains A/Swine/Tatarstan/64 and A/Swine/Ikshurminsk was shown to belong to the subtype N1 but to differ from neuraminidase of the strain A/Swine/Iowa/15/30. Neuraminidase of the strain A/Chicken/USSR/314/67 differs from neuraminidases of A/PR8/34, A/WS/33, and A/Swine/Iowa/15/30 but is related to neuraminidases of the strains A/New Jersey/8/76, A/duck/Germany/1868/68 and A/Chicken/Scotland/59.