The effectiveness of a mental health, parenting support, and violence prevention program for families affected by the war in Ukraine: Findings from a pre-post study.

Background: Nearly one in six children lived in war zones in 2023. Evidence-based psychosocial and parenting support has potential to mitigate negative impacts for parents and children co-exposed to war and displacement, especially in relation to mental health and harsh parenting reactions. In the current war in Ukraine, local mental health experts co-created and evaluated, with global experts, the effectiveness of psychosocial and parenting support groups, called on improvements in mental health, positive parenting, and violence against children.

Genetically encoded discovery of perfluoroaryl macrocycles that bind to albumin and exhibit extended circulation in vivo.

Peptide-based therapeutics have gained attention as promising therapeutic modalities, however, their prevalent drawback is poor circulation half-life in vivo. In this paper, we report the selection of albumin-binding macrocyclic peptides from genetically encoded libraries of peptides modified by perfluoroaryl-cysteine SAr chemistry, with decafluoro-diphenylsulfone (DFS). Testing of the binding of the selected peptides to albumin identified SICRFFC as the lead sequence.

Identification of the Natural Frequencies of Oscillations of Perforated Vibrosurfaces with Holes of Complex Geometry.

The reliability of perforated vibrosurfaces is one of the main parameters of the efficiency of their operation in many technological processes. Existing methods for studying vibrosurfaces with standard single holes and the corresponding results cannot be used to study the reliability of vibration surfaces with holes of complex geometric shapes. The proposed method is based on the experimental modal identification of the parameters of natural oscillations, the parallel creation of a numerical model using the finite element method, and the comparison of the results.

Dexmedetomidine versus propofol sedation in flexible bronchoscopy: a randomized controlled trial.

Background: Dexmedetomidine (DEX), is a highly selective alpha2 adrenoceptor (α2-AR) agonist, successfully used in various procedures including flexible bronchoscopy. Randomized controlled trials (RCTs) evaluating DEX sedation during bronchoscopy report equivocal results regarding respiratory and hemodynamic outcomes.

Methods: We conducted an RCT to evaluate the efficacy and safety of dexmedetomidine compared to propofol for sedation during bronchoscopy.