[Medical and Dosimetric Register of the Siberian Group of Chemical Enterprises Personnel--the Basis for the Evaluation of Chronic, Radiation Exposure Effects].

The characteristic of medical and dosimetric register database of Siberian Group of Chemical Enterprises personnel is represented. This characteristic includes the description of the database structure, main sources of information, quantitative composition of the cohort under study, methods of evaluation of the external and internal irradiation doses, modern data on cancer incidence and reasons of death. The database is the basis for estimating the risk of the cancer and non-cancer effects after a long-term radiation exposure and dependence of "dose-response" at different levels: from population and group to cell and molecular.

[Features of a cytokine profile in patients with chronic glomerulonephritis with progressive chronic renal failure].

Aim: To specify the cytokine profile in chronic glomerulonephritis (CGN) with aggravating renal function, to assess prognostic value of some cytokines in development of CGN in these patients.

Material And Methods: Indices of the cytokine profile were followed up in 56 CGN patients with nephrotic syndrome and arterial hypertension and compared in those patients who developed CGN for 2 years (group 2) versus patients with intact renal function (group 1).

Results: Serum levels of IL-1beta and TNF-alpha were maximal in CGN patients with aggravating renal function.

[Beta-carotene prevention of immune disorders in workers engaged in the fire copper refining].

The paper deals with the studies of the human status and immunological responsiveness of workers engaged in copper-smelting industry. The examinees were found to more frequently develop lower environmentally induced immunological responsiveness followed by leuko- and lymphopenia, higher lymphocytic CD4+/CD8+ ratios, phagocytic dysfunction in peripheral blood. Preventive use of beta-carotene prevented negative changes in immunological parameters.

ATP-sensitive K(+)-channels in the human adult ventricular cardiomyocytes membrane.

Using the patch-clamp method in 27 different inside-out patches it was shown for the first time that they defined the basic parameters of the functioning of single ATP-sensitive K+ channels in the human adult ventricular cardiomyocytes membrane. At [K+]o = 140 mM single channel conductance (over the linear part of the I-V relation) reaches 100 pS. The possibility of the existence of these channels' conductance sublevels as well as the cluster character of their localization in sarcolemma is shown.

[Activation of ATP-sensitive K+-channels of cardiomyocytes by endogenous cardiopeptides].

The "patch-clamp" method was applied to rat ventricular cardiomyocytes to study the effect of endogenous cardiopeptides (a component of a cardiologic medicine "cardialin") on single K(+)-channel currents. It was noted that ATP-sensitive K(+)-channel activity increased only in the presence of 10(-8)-10(-6) mg.ml-1 peptide solution in the patch-clamp micropipette.