[Metabolic effects of static physical load under the conditions of pharmakologicheskoĭ mobilization of physical endurance].

The model of static physical loading (SPL) was used to study the biochemical effects of graded static tension and potentiality for pharmacological mobilization of physical endurance with participation of male volunteers. A close pathogenetic linkage between the established metabolic effects of the model and their adaptive adequacy to the stressing factor show that there is every reason to arrange the observed shifts in a SPL syndrome. The SPL syndrome is primarily manifested by exaggerated tone of the adrenoactive structures, inhibition of insulin production by the pancreas, activation of the neuropeptide anti-stress mechanisms, predominant utilization of the lipid substrate in energy production, intensification of protein catabolism, and increase in myocyte membrane permeability due to energy deficit.

[Value of several hormone indicators and cyclic nucleotides in the assessment and prognosis of resistance to acute hypoxia during operator activities].

A study was performed in which 16 healthy volunteers, aged 25-40 years, worked in a two-dimensional tracking simulator and breathed a mixture containing 9-12% oxygen. This led to a higher incretion of cortisol, insulin, somatotropin, a greater renal excretion of epinephrine, norepinephrine, and a higher content of cAMP in lymphocytes, plasma and urine. The subjects with a higher insulin in plasma and renal excretion of catecholamines showed a longer time of tolerance to the above exposure which varied from 50 to 120 min.

[Informative value of the studies of beta 2-microglobulin in the plasma and urine of humans for evaluation of the resistance to static and bicycle ergometry tests].

Changes of the beta 2-microglobulin concentration in blood and urine were measured in response to static and bicycle ergometry tests. In both cases, the concentration of beta 2-microglobulin in urine increased. A higher level of its renal excretion was seen in stable subjects before and after the tests.