Neurodevelopmental outcomes after infant heart surgery for congenital heart disease: a hospital-based multicentre prospective cohort study from India.

Background: Neurodevelopmental disability is a common long-term concern following surgery for congenital heart disease (CHD). Little information is available from low-resource environments where the majority of children with CHD are born. Several challenges in the CHD care continuum exist in such environments.

Large-scale evaluation of outcomes after a genetic diagnosis in children with severe developmental disorders.

Purpose: We sought to evaluate outcomes for clinical management after a genetic diagnosis from the Deciphering Developmental Disorders study.

Methods: Individuals in the Deciphering Developmental Disorders study who had a pathogenic/likely pathogenic genotype in the DECIPHER database were selected for inclusion ( = 5010). Clinical notes from regional clinical genetics services notes were reviewed to assess predefined clinical outcomes relating to interventions, prenatal choices, and information provision.

Foliar image-based characterization of airborne particulate matter in an urban area and its implications for remediation.

This study addresses the pervasive issue of particulate matter (PM) emission in urban areas, proposing a better approach using scanning electron microscope (SEM) techniques to identify plant species effective in airborne PM removal. Conducted in Bilaspur city, the research strategically selected six plant species across four distinct sites and applied the SEM-Image J method for analysis, yielding significant insights, especially in the respirable PM range. Among the tested plant species, Senna Siamea and Dalbergia Sissoo emerged as consistent and standout performers, displaying the highest PM removal efficiency across all sites.

Synthesis and Biological Evaluation of 5'-Deoxy-adenosine Derivatives as A Adenosine Receptor Ligands.

The A Adenosine Receptor (AAR) is an important therapeutic target due to its role in inflammation and immune response regulation. Herein, we synthesized and evaluated 5'-deoxy-adenosine derivatives with oxygen at the 4'-position, comparing them to previously studied 4'-thionucleosides. Compound exhibited the highest binding affinity ( = 5.

Unravelling the Unseen: A Case Series Exploring the Enigmas of Traumatic Optic Neuropathy.

Traumatic optic neuropathy (TON) is a rare condition resulting from damage to the optic nerve due to craniofacial trauma. It can present as direct or indirect injuries, with mechanisms ranging from mechanical disruption by fractures in direct TON to transmitted forces causing shearing and ischemia in indirect TON. These injuries often lead to significant visual impairment or complete vision loss, requiring timely diagnosis and intervention.