[Dynamics of a series of parameters of cellular and humoral immunity in patients with diabetes mellitus type I].

Fifty-two patients with type I diabetes mellitus were examined. The patients were divided into 4 groups with various duration of the disease: group 1 included patients with the newly diagnosed disease, group 2 those with disease standing of 1 to 5 years, group 3 were patients suffering from diabetes for 6 to 10 years, and group 4 were diabetics for 10 years and more. The parameters examined were antibodies to surface antigens of islet cells, absolute and relative counts of T and B lymphocytes in the peripheral blood, counts of T- helpers and T-suppressors and cytotoxic cells and their ratios, counts of natural killers, DR (+) and JgG (+) cells, and basal C-peptide level.

[Cellular immunity in patients with newly detected insulin-dependent diabetes mellitus].

Twenty-five diabetics with insulin-dependent condition were examined at the debut of the disease before insulin therapy, as were 10 healthy donors. Under study were relative and absolute counts of T lymphocytes, NK cells, B lymphocytes, DR-T lymphocytes, Th, Ts, and Th/Ts index. Patients' and donors' sera were tested for autoantibodies to P64-69kD antigenic complex.

[Determination of autoantibodies to pancreatic beta-cells, non-islet endocrine cells and fibroblasts in patients with newly detected diabetes mellitus].

The clinical onset of insulin-dependent diabetes (IDD) is characterized by the onset of circulation of autoantibodies to beta-cells. Thirty-three newly detected IDD patients and 14 newly detected patients with noninsulin-dependent diabetes mellitus were examined for autoantibodies to antigen P 64-69, to surface antigen of islet cells, to thyrocyte microsomal fraction, thyroglobulin, hypophysis, fibroblasts; the levels of circulating immune complexes were measured as well. IDD debut was found associated with the appearance of antibodies to pancreatic islet cells, thyroid, thyroglobulin, hypophysis, fibroblasts, this indicating a polyclonal activation of the immunity system.

[Dynamics of disorders of cellular and humoral immunity parameters in patients with insulin-dependent diabetes mellitus].

Analysis of immunocompetent cell subsets in peripheral blood of patients with insulin dependent diabetes mellitus (IDDM) and the determination of sICA-autoantibodies in their sera were performed by flow rate cytometry and compared to healthy donors and patients with noninsulin-dependent diabetes mellitus (NIDDM). It was shown that newly diagnosed IDDM was characterized by predominant disturbances of humoral immunity, and disease progression was mainly accompanied by cellular immunity disturbances. Exogenous insulin was one of the causes of such disturbances.