Optimisation of the deployment of automated external defibrillators in public places in England.

Background: Ambulance services treat over 32,000 patients sustaining an out-of-hospital cardiac arrest annually, receiving over 90,000 calls. The definitive treatment for out-of-hospital cardiac arrest is defibrillation. Prompt treatment with an automated external defibrillator can improve survival significantly.

Adolescents with Normal Weight Obesity Have Less Dry Lean Mass Compared to Obese Counterparts.

Normal weight obesity (NWO) is a condition characterized by a normal body mass index (BMI; 18.5-24.9 kg·m) yet excess body fat.

Rural Reflections of Appalachia: A Qualitative Study of Health Professional Students' Experiences from a Rural Immersion Experience in West Virginia.

Introduction: Conventional academic rotations lack in-depth exposure to rural community members, systems, and resources surrounding specific rural-focused health issues.

Purpose: This study aims to explore health professional students' experiences within a community-based multidisciplinary rural immersion through their personal reflections.

Methods: Written reflective entries were extracted from the online classroom system from 2019-2021.

Are Small Teams a Viable Strategy to Deliver Early Psychosis Intervention Services in Rural Areas? An Ontario Fidelity Study.

Early psychosis intervention (EPI) is a complex model of care designed to be delivered by a large multidisciplinary team. However, in practice, it is often delivered by very small teams, particularly in rural areas. This study analyzed fidelity data from over half of Ontario EPI programs (n = 24) to compare model fidelity in programs with smaller (≤2.

AMPK signaling is dysregulated in human tendinopathy and loss of AMPKα1 leads to cell, matrix and mechanical dysfunction in mouse Achilles tendon.

Tendinopathy is a tendon disorder that is caused by the failure to self-repair and has many pathological characteristics such as disorganized ECM and decreased cell viability. We have identified a possible target to combat these changes, AMPK, an energy stress sensor that was shown to maintain intracellular homeostasis. Through bulk RNA-sequencing of healthy and tendinopathic tendons from humans we have identified a novel finding of downregulation of AMPK signaling in the tendinopathic samples which suggests AMPK plays a role in tendon homeostasis.