[Efficiency of surgical treatment of varicocele for restoration of reproductive function].

It was examined 206 patients with varicocele and infertility in infertile men aged from 25 to 45 years. Stightly best results were obtained after microsurgical operation. Surgical removal of a varicocele as a stage of infertility treatment should not be done as long as interviewed with sterile pair about absence warranty the success of this method of treatment.

[Clinical and immunological studies of the therapeutical effect of cytokines combined with 5-fluorouracil in metastatic kidney cancer].

The authors present the results of a six-year clinicoimmunological study of a therapeutic effect of cytkins combined with 5-fluoruracyl in metastatic renal-cell carcinoma. Two therapeutic regiments have been used: rhIFN-a + 5-FU and rhIL-2 + RHifn-A + 5-FU. In cytokin-sensitive patients, both therapy protocols vrs conventional therapeutic alternatives (cytostatics, hormones, irradiation) have been shown to increase the frequency of achievement of remission by objective scoring and life span of the patients.

[The prognostic significance of the PCNA protein in transitional-cell bladder cancer].

1. Apparent expression of PCNA in different tumours should not be regarded as an unquestionable criterion of tumoral growth and progression but a negative result of an immunohistochemical assay for PCNA of certain human tumours is not to be taken as a proof that there is no tumoral growth whatever. 2.

[Alterations of nucleoli and nucleolar organizers in proliferative cystitis and transitional cell carcinoma of the urinary bladder].

The values of the nucleolar and granular rates as well as the number of Ag-granules were increased during the process of malignancy of transitional epithelium in proliferative chronic cystitis and transitional cell bladder carcinoma, including invasive tumours at both ultrastructural and light microscopic levels. The results may serve as additional criteria in the assessment of the risk of bladder mucosa malignancy and prognosis of the transitional cell bladder carcinoma.