[Results of chemotherapy in patients with disseminated testicular tumors].

Results of treatment of 44 patients with disseminated non-seminomatous testicular tumors versus advancement are discussed in the paper. In cases of minimal and moderate advancement (group 1), induction chemotherapy included three cycles of VAB-6 regimen (vinblastine, actinomycin D, bleomycetin, cyclophosphamide plus 120 mg/m2 platidiam) whereas cases of advanced tumor (group 2) received six such cycles; two of them used 150 mg/m2 platidiam dropwise in a 3% sodium chloride solution. Complete regression was observed in 22 of 24 (96.

[Mental disorders during chemotherapy of malignant testicular neoplasms].

Mental disorders developed during the chemotherapy of malignant testes tumors are described as related to the patients' personality traits and their psychogenic response to the disease. In 19 patients treated with Platinum-containing drugs, various mental disorders were noted: asthenic, neurotic, psychopath-like ones which were most marked in cycloid-, epileptoid- and schizoid-accentuated personalities, and in the cases with pronounced psychogenic response to the disease and surgery. The latter response could appear as astheno-depressive, anxious-depressive, astheno-neurotic states.

[Elaboration of the combination of antitumor preparations bleomycetin + 5-fluorouracil + cisplatin].

Clinical trials on efficacy and toxicity of combined use of bleomycetin, 5-fluorouracil and cisplatin in patients with disseminated tumor processes were conducted. Two regimens were applied. Regimen I included intravenous administration of cisplatin in a dose of 100-150 mg/m2 on day 1, intramuscular administration of bleomycetin in a dose of 10 mg on days 2-4 and intravenous jet injection of 5-fluorouracil in a dose of 400 mg/m2 on days 2-4.