Significance of adhesion molecules expression for estimation of serous ovarian cancer prognosis.

Aim: To study the adhesion molecules CD44 and E-cadherin expression in serous ovarian cancer (OC) and their relationship with clinicopathological peculiarities of tumor process and prognosis.

Materials And Methods: The study was performed on OC samples from 72 patients with serous OC of stages I-III. Expression of CD44 and E-cadherin in tumor samples was evaluated with the use of immunohistochemical analysis.

[Immunocorrective effect of cycloferon and thymogen in patients with uterine cancer].

Those women diagnosed as having hysterocarcinoma demonstrate even before surgery pronounced immunological disturbances tending to progress after surgical intervention. The employment of cyclopheronum and thymogenum makes for normalization of values for the immune status. Clinically, this is accompanied by a more favourable postoperative course.

[The endogenous intoxication syndrome and indices of the adenyl system and microhemodynamic in patients with uterine cancer].

Women diagnosed as having hysterocarcinoma (HC) demonstrate even prior to surgical intervention manifest abnormalities in metabolic indices, such as increase in the level of medium-size molecules, decrease in the blood content of adenosine triphosphatase, and profound disturbances in microhemodynamics. The most significant abnormalities of metabolism and microcirculation occur in clinical stage III HC against the background of concomitant somatic pathology, diabetes mellitus, arterial hypertension, adiposis in particular.

[The influence of the combined treatment on the energy metabolism in patients with the uterine cancer].

The experience of management of the patients with cancer of the uterus body was summarized to improve the results of combined (surgical and radiation) treatment. The essential initial disorders of the power supply metabolism, keeping worsening after the operation, were revealed. The conduction of the immune correction therapy in complex of preoperative preparation with individual selection of the immune preparations using the tests in vitro had promoted the postoperative period course improvement, the frequency of complications reduction, the stabilization and tendency for the power supply metabolism restoration after the operation and further during the radiation therapy conduction.

[Indices of lipid peroxidation and antioxidant defense system and prostanoid level in patients with uterine cancer].

The state of peroxydal oxidation of lipids, system of antioxidant defense and content of prostanoids in patients with cancer of the corpus uteri were investigated. Syndrome of endogenous intoxication with lowering of antioxidant potential and dysbalance of cyclic nucleotides and prostaglandines was established. The severity of above-cited disorders increased significantly after operation and during conduction of radiotherapy.