Publications by authors named "S V A Chamila Samarasinghe"
A 1.5 to 3 Mb microdeletion of chromosome 22q11.2 with loss of multiple genes including histone cell cycle regulator (HIRA) causes 22q11.
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- The study examined the causes and outcomes of acute kidney injury (AKI) in 464 patients at a tertiary care center in Sri Lanka, highlighting the influence of age, comorbidities, and severity on patient prognosis.
- Of the patients, 56.5% were male, with a mean age of 57.04 years; by 90 days, most patients showed improvement in renal function, though mortality rates were highest in those over 60 and with more severe AKI.
- The research identified major challenges in AKI management, including inadequate resources and infrastructure, underscoring the importance of early identification and intervention for at-risk populations.
Effectiveness of selective antibiotics use in ESBL-related UTIs.
Aththanayaka Mudiyanselage Waththe Gedara Kasun Prabuddha Aththanayaka Gangulwitiya Gamage Yasodha Hansani Weerasinghe Nimsha Sevwandika Weerakkody Samarasinghe Herathge Gayani Geethika Samarasinghe Upul Priyadharshana
BMC Microbiol
September 2024
Article Synopsis
- Urinary tract infections (UTIs) affect millions globally, with a rising concern over Enterobacteriaceae species that produce extended-spectrum β-lactamases (ESBLs), making treatment more challenging.
- A study at a district hospital in Polonnaruwa analyzed 4386 urine specimens, revealing 200 cases with ESBL isolates, primarily E. coli, especially among patients aged 55-74 and predominantly from the In-Patient Department.
- The research highlighted Mecillinam and Nitrofurantoin as the most effective oral antibiotics against E. coli and other species, with Nitrofurantoin showing notable effectiveness against Klebsiella spp. and other Enterobacteriaceae.
Article Synopsis
- Cutaneous leishmaniasis in Sri Lanka is unusual, as it is typically caused by Leishmania donovani, which is mainly associated with visceral disease.
- Genome analysis of clinical isolates from Sri Lanka revealed that both L. donovani and L. tropica are present, with some L. tropica strains linked to older Indian isolates rather than recent hybrids.
- The findings suggest that L. donovani is not the sole cause of cutaneous leishmaniasis in Sri Lanka, pointing to potential interspecies hybrids contributing to the disease.
Introduction: Carotid endarterectomy is performed for patients with symptomatic carotid artery occlusions. Surgery can be performed under general and regional anesthesia. Traditionally, surgery is performed under deep cervical plexus block which is technically difficult to perform and can cause serious complications.
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