Effect of an Overnight Stay at 2500 m on Nocturnal Hypoxemia and Sleep-disordered Breathing in Patients with Pulmonary Vascular Disease: A Randomized Trial.

Background: Patients with pulmonary vascular disease (PVD) often reveal nocturnal hypoxemia and sleep apnea. We investigated whether exposure to high altitude worsens those conditions.

Methods: In a randomized-controlled crossover trial, stable patients with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH) without resting hypoxemia (PaO2 >8 kPa at low altitude) underwent respiratory polygraphy at 470 m and during an overnight stay at 2500 m.

Enhancing WRAP-based Nanoparticles for siRNA Delivery in pH-Sensitive Environments.

SiRNA are promising therapeutic molecules that require delivery systems to reach their targets. Several siRNA delivery systems, such as lipid- or peptide-based nanoparticles, have been developed. In this context, we previously conceived a cell-penetrating peptide WRAP5 forming nanoparticles in the presence of siRNAs and validated the efficiency of this delivery system in inhibiting protein expression.

Impact of the establishment of a multidisciplinary national chronic thromboembolic pulmonary hypertension board on a monocentric surgical endarterectomy program.

Objectives: Chronic thromboembolic pulmonary hypertension is a rare disease, characterized by delays in diagnosis and curative surgical treatment. After establishing a surgical pulmonary endarterectomy centre in Switzerland and due to a historically low resection rate of 14%, a national multidisciplinary evaluation board was established in January 2018. Herein, we summarize the impact of the board on our programme.

Photon-Counting Detector CT Iodine Maps Versus SPECT/CT: Advancing Lung Perfusion Imaging in Chronic Thromboembolic Pulmonary Hypertension.

Objectives: The aim of this study was to compare the accuracy of photon-counting detector computed tomography (PCD-CT) iodine maps of the lung parenchyma with perfusion scintigraphy for detection and extent estimation of pulmonary perfusion defects.

Materials And Methods: This institutional review board-approved retrospective study included 26 subjects (11 male, aged 57.2 ± 15.

Peak Eccentric Cycling Exercise and Cardiorespiratory Responses to Normobaric Hypoxia Versus Normobaric Normoxia in Healthy Adults: A Randomized, Controlled Crossover Trial.

: Pulmonary rehabilitation clinics are traditionally located at higher altitudes (HAs), where lower PO reduces exercise capacity and blood oxygenation. Eccentric cycling exercise (ECC), with its lower cardiorespiratory demand compared to concentric cycling (CON), might therefore be a potential advantageous training modality at HAs, particularly for individuals with reduced exercise capacity. This study aimed to compare the cardiorespiratory responses of ECC while breathing normoxic versus hypoxic gas in healthy participants.