Impact of operating parameters on the electrooxidation of methylene blue and ciprofloxacin: a comprehensive analysis and degradation pathway.

In recent decades, freshwater bodies have experienced significant stress due to the excessive disposal of dyes from textile industries and waste antibiotic discharges from pharmaceutical industries. The continuous disposal of these substances may harm the natural ecosystem and generate antibiotic resistance in living organisms. Conventional treatment facilities are inadequate in treating these contaminants effectively, leading to a focused interest in advanced technologies, such as electrooxidation.

Phytotoxic impact of di-butyl phthalate (DBP) on physiological, biochemical, and oxidative stress parameters of rice (Oryza sativa).

Phthalates are synthetic compounds, well-known plasticizers, with numerous applications and reported to have adverse effects on all living organisms residing in terrestrial and aquatic environments. In this study, the rice (Oryza sativa) seedlings were exposed to di-butyl phthalate (DBP) exogenously for 7 days, with varying concentrations of 0, 200, 400, 800, and 1600 mg/L, to explore the toxicological, physiological, and biochemical consequences by measuring various parameters such as pigment, lipid, and HO (hydrogen peroxide) contents. The biochemical analysis of seedlings showed that the pigments, lipids, and HO concentrations were altered abnormally.

Abortion and unintended pregnancy in Pakistan: new evidence for 2023 and trends over the past decade.

Background: Despite induced abortion being highly legally restricted in Pakistan, studies in 2002 and 2012 showed that many women rely on abortion when faced with an unintended pregnancy. Following the 2012 study, concerted efforts were made to improve contraceptive services and to strengthen postabortion care. The availability and use of misoprostol also expanded in the past decade.

Discovery of pyrazoline analogs as multi-targeting cholinesterase, β-secretase and Aβ aggregation inhibitors through lead optimization strategy.

The multi-target directed ligands (MTDLs) strategy has been evolved as the propitious approach for the development of therapeutics for Alzheimer's disease (AD). In an earlier report, we described the novel series of chalcone derivatives bearing N-aryl piperazine scaffold as MTDLs for the treatment of AD. Herein, we report the lead optimization of the series culminating in potent, multi-targeting compounds (32-57), evaluated through in-vitro and in-vivo biological studies.

A new phytopharmaceutical obtained from Polyalthia longifolia with Anti-dyslipidemic potential: Mechanistic pathway insights exploiting co-inverse miRNA-mRNA expression analysis.

Obesity and its associated metabolic disorders are significant global health challenges, necessitating novel therapeutic approaches. This study explores the anti-adipogenic and anti-dyslipidemic properties of 4655-EF, a novel phytopharmaceutical derived from Polyalthia longifolia, and explores the molecular pathways involved in its pharmacological activity. This phytopharmaceutical was prepared using a bioactivity-guided supercritical fluid extraction method suitable for large-scale production.