A generalizable Hi-C foundation model for chromatin architecture, single-cell and multi-omics analysis across species.

Nuclear DNA is organized into a compact three-dimensional (3D) structure that impacts critical cellular processes. High-throughput chromosome conformation capture (Hi-C) is the most widely used method for measuring 3D genome architecture, while linear epigenomic assays, such as ATAC-seq, DNase-seq, and ChIP-seq, are extensively employed to characterize epigenomic regulation. However, the integrative analysis of chromatin interactions and associated epigenomic regulation remains challenging due to the pairwise nature of Hi-C data, mismatched resolution between Hi-C and epigenomic assays, and inconsistencies among analysis tools.

Genetic mapping and validation of QTL controlling fruit diameter in cucumber.

Fruit diameter is one of important agronomy traits that has greatly impacts fruit yield and commercial value in cucumber (Cucumis sativus L.). Hence, we preliminary mapping of fruit diameter was conducted to refine its genetic locus.

L47 and inulin affect colon and liver inflammation in piglets challenged by enterotoxigenic through regulating gut microbiota.

Introduction: Infection by pathogenic bacteria during weaning is a common cause of diarrhea and intestinal inflammation in piglets. Supplementing the diet with synbiotics is beneficial for animal health. The strain of L47 (L47) isolated in our lab exhibited good probiotic properties when combined with inulin.

Hydroxamate Siderophores Intensify the Co-Deposition of Cadmium and Silicon as Phytolith-Like Particulates in Rice Stem Nodes: A Natural Strategy to Mitigate Grain Cadmium Accumulation.

Sequestration of cadmium (Cd) in rice phytolith can effectively restrict its migration to the grains, but how hydroxamate siderophore (HDS) affects phytolith formation within rice plants especially the fate of Cd and silicon (Si) remains poorly understood. Here, we found that the addition of HDS increased the content of dissolved Si and Cd in soil pore water as well as its absorption by the rice roots during the reproductive growth stage. HDS effectively trapped orthosilicic acid and Cd ions at the third stem nodes of rice plants via hydrogen bonds and chelation interactions, which then rapidly deposited on the xylem cell wall through hydrophobic interactions.