A Case of Advanced Biliary Tract Cancer With EGFR Amplification That Responded to Necitumumab.

Background: Recent advances in cancer genome analysis and the practice of precision medicine have made it possible to identify fractions with rare genetic alterations. Among biliary tract cancers, EGFR-amplified cancers are known to be rare fractions across organs and have a poor prognosis. The use of anti-EGFR antibody for EGFR-amplified cancers has been promising; however, the evidence is not yet clear.

Facile Depolymerization of Thermally Stable Polyetherethersulfone and Polyetheretherketone Using Hydroquinone and Bases.

Super engineering plastics such as polyetheretherketone (PEEK) and polyetherethersulfone (PEES) exhibit thermal stability, chemical resistance, and mechanical strength. Such characteristics are attributed to their robust chemical structures composed of stable aryl ethers. These features make chemical recycling difficult.

[Approaches and Challenges in the Clinical Application of On-Body Injector(G-Lasta BodyPod)].

The G-Lasta BodyPod(BodyPod), a newly developed on-body injector that automatically injects pegfilgrastim(Peg-G), has been approved for clinical use in Japan. However, its precise operation is yet to be established. Exploring accumulated literature, we reviewed the efficacy and safety of the Peg-G on-body injector used in other countries and determined its eligibility criteria, operating procedures, and troubleshooting guideline.

Activation of STING in pancreatic cancer-associated fibroblasts exerts an antitumor effect by enhancing tumor immunity.

Pancreatic ductal adenocarcinoma (PDAC) has a high mortality rate; therefore, the development of effective treatments is a priority. The stimulator of interferon genes (STING) pathway enhances tumor immunity by inducing the production of type 1 interferon (IFN) and proinflammatory cytokines and chemokines and promoting the infiltration of cytotoxic T cells. To assess the function of STING on pancreatic tumorigenesis, Ptf1a LSL-Kras p53 mice (KPC mice) and Ptf1a LSL-Kras p53/STING mice (KPCS mice) were generated.