Publications by authors named "S Tsubaki"

sp. is a type of green algae and is widely distributed in coastal areas around the world due to eutrophication. Effective utilization of sp.

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  • * Using mouse models treated with clodronate-liposomes to deplete macrophages, researchers found that Klebsiella pneumoniae can damage the intestinal lining and spread to the liver.
  • * The findings highlight the crucial role of intestinal macrophages in preventing the translocation of commensal K. pneumoniae to the liver, suggesting that these mouse models can be useful for developing treatments to combat K. pneumoniae infections.
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In the alkyl addition reaction of aromatic nitriles using Grignard reagents, ketones are formed after hydrolysis. However, this addition reaction is often slow compared to that using reactive organolithium(i) reagents. In this study, we improved the reaction by using zinc(ii)ates, which are generated using Grignard reagents and zinc chloride (ZnCl) as a catalyst.

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A sintered lunar regolith is expected to be used to construct buildings, roads, and landing pads for spacecrafts on the Moon. Here, we demonstrate that focused microwave heating is effective for the rapid solidification of the lunar regolith simulant to obtain regolith gravel without any microwave susceptor. The conventional multimode microwave oven cannot heat lunar regolith simulants and requires microwave susceptors such as silicon carbide (SiC) and thermal insulators because of its low dielectric loss.

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  • Adherent-invasive Escherichia coli (AIEC) is linked to Crohn's disease and has a unique ability to invade the intestinal lining, but how it became invasive is still unclear.
  • In research, it was discovered that AIEC produces more flagellin (fliC) compared to non-AIEC strains, leading to longer flagellar filaments crucial for its invasion and movement capabilities.
  • The study also revealed that a molecule called cyclic-di-AMP (c-di-AMP) can enhance fliC expression and flagellar development in both AIEC and non-AIEC strains, suggesting a potential mechanism for inducing invasive behavior even in non-invasive bacteria.
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