Oseltamivir Reduces 30-Day Mortality in Older Adults With Influenza: A Pooled Analysis From the 2012-2019 Serious Outcomes Surveillance Network of the Canadian Immunization Research Network.

Background: Oseltamivir is recommended for the treatment of adults hospitalized with influenza, but adherence is often suboptimal. This may be due to doubts about the reliability of the evidence supporting its benefits, particularly when initiation is delayed. We aimed to assess the effectiveness of oseltamivir in reducing mortality in older adults hospitalized with influenza, with a focus on the timing of initiation.

Impact of SARS-CoV-2 vaccination and of seasonal variations on the innate immune inflammatory response.

Introduction: The innate immune response is an important first checkpoint in the evolution of an infection. Although adaptive immunity is generally considered the immune component that retains antigenic memory, innate immune responses can also be affected by previous stimulations. This study evaluated the impact of vaccination on innate cell activation by TLR7/8 agonist R848, as well as seasonal variations.

Expressive Writing About One's Trauma Increases Accessibility of Cannabis Information in Memory Among Trauma-Exposed Individuals.

Objective: Trauma survivors are more likely than others to use cannabis, and post-traumatic stress disorder (PTSD) commonly co-occurs with cannabis use disorder (CUD). Automatic memory associations between trauma reminders and cannabis use have been suggested as contributing mechanisms. These associations can be studied experimentally by manipulating trauma cue exposure in a cue-reactivity paradigm (CRP) and examining effects on the accessibility of cannabis information in memory in trauma survivors with and without PTSD.

Infection Rate and Risk Factors of SARS-CoV-2 Infection in Retail Workers at the Onset of the COVID-19 Pandemic, Quebec, Canada.

During the pandemic, client-facing workers were perceived to be at greater risk of SARS-CoV-2 infection. This study investigated the risk factors for SARS-CoV-2 infection among a cohort of 304 retail workers in the Quebec City metropolitan area. After providing consent, participants were interviewed to gather information on demographic, socioeconomic, behavioural, and occupational variables.

Towards the standardization of Hydra vulgaris bioassay for toxicity assessments of liquid samples.

The Hydra vulgaris bioassay is recognized as sensitive invertebrate test species for toxicity assessment of real-life environmental mixtures for enforcement and monitoring investigations. The purpose of this study was to characterize the intra-laboratory variability, study the influence of environmental variables (temperature, luminosity, inter-individual and day of analysis) on ZnSO toxicity, a reference model toxicant for hydra. The sublethal (effect concentration for 50 % of hydra-EC50) and lethal (lethal concentration for 50 % of hydra-LC50) were determined based on characteristic morphological changes for this species.