Publications by authors named "S Trefely"
Brown adipose tissue (BAT) engages futile fatty acid synthesis-oxidation cycling, the purpose of which has remained elusive. Here, we show that ATP-citrate lyase (ACLY), which generates acetyl-CoA for fatty acid synthesis, promotes thermogenesis by mitigating metabolic stress. Without ACLY, BAT overloads the tricarboxylic acid cycle, activates the integrated stress response (ISR) and suppresses thermogenesis.
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- The placenta plays a key role in managing nutrient exchange between the mother and fetus, and its development is influenced by nutritional factors.
- The research by Yu et al. identifies the intertwined metabolic and epigenetic changes involved in the formation of syncytiotrophoblasts (syncytialization).
- They highlight that a specific metabolite, acetyl-CoA, which is affected by glucose metabolism, is essential for this process.
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- Scientists studied how a substance called propionate affects heart function in mice that have a specific health problem.
- They found that female mice showed more heart changes than male mice when they had too much propionate.
- This imbalance caused issues with how the heart functions, leading to problems with blood flow and heart muscle contractions.
Endothelial-to-mesenchymal transition (EndMT), a process initiated by activation of endothelial TGF-β signaling, underlies numerous chronic vascular diseases and fibrotic states. Once induced, EndMT leads to a further increase in TGF-β signaling, thus establishing a positive-feedback loop with EndMT leading to more EndMT. Although EndMT is understood at the cellular level, the molecular basis of TGF-β-driven EndMT induction and persistence remains largely unknown.
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