Publications by authors named "S Tourpin"
The generation of oocytes from induced pluripotent stem cells (iPSCs) was proven efficient with mouse cells. However, no human iPSCs have yet been reported to generate cells able to complete oogenesis. Additionally, efficient sorting of human Primordial Germ Cell- Cells (hPGC-LCs) without genomic integration of fluorescent reporter for their downstream manipulation is still lacking.
View Article and Find Full Text PDFMale gametogenesis involves both mitotic divisions to amplify germ cell progenitors that gradually differentiate and meiotic divisions. Centrosomal regulation is essential for both types of divisions, with centrioles remaining tightly paired during the interphase. Here, we generated and characterized the phenotype of mutant mice devoid of , a gene encoding for a docking protein for fibers linking centrioles, and characterized their phenotype.
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- Primary ovarian insufficiency (POI) affects around 1% of women under 40, and genetic causes, including DNA repair variants, have been linked to this condition, with a case of isolated POI reported in a Turkish family.
- Exome sequencing revealed a specific BRCA2 variant in the patient, and various functional tests indicated that this variant affects genetic repair processes, although no cancer or syndromic traits were evident.
- The study broadens the understanding of BRCA2 mutations by linking a specific variant to isolated POI, which can influence patient management and genetic counseling strategies for those affected.
Article Synopsis
- In female mammals, germ cells start meiosis in the fetal ovaries, while in males, it's delayed until after birth, with retinoic acid (RA) playing a key role in this process.
- CYP26B1, an enzyme that breaks down RA, is crucial for preventing meiosis in fetal testes, but the influence of RA in female meiosis has not been clearly demonstrated before.
- This study shows that while CYP26B1 effectively stops meiosis in female germ cells, RA appears to enhance STRA8 expression rather than directly trigger it, suggesting more complex interactions that should prompt further research into substances that regulate meiosis.
Article Synopsis
- The study found that adult male mice have greater oligodendrocyte density and thicker myelin sheaths compared to females, and these differences emerge during the first 10 days after birth.
- Higher androgen levels in males during this period were linked to the differentiation of oligodendrocyte progenitor cells.
- The research highlights the critical role of postnatal androgen signaling in determining myelin characteristics and suggests implications for understanding neurodevelopmental disorders and sex differences in conditions like multiple sclerosis.