Publications by authors named "S Tournis"
Introduction: Phenylketonuria (PKU), an inborn error of metabolism, when inadequately treated, may lead to nutritional deficits, which could affect bone health. This remains a controversial issue, given that in the majority of PKU cases, bone mineral density is within normal limits. On the other hand, WNT1 mutations are detrimental for bone, as they lead to primary osteoporosis.
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- The study aimed to assess how common sarcopenia (muscle loss) is in post-menopausal women with rheumatoid arthritis (RA) and its relationship with disease factors.
- Out of 80 RA patients, 39% were found to have sarcopenia, while none of the control group had it, indicating a significant difference.
- Sarcopenic RA patients exhibited lower body mass index (BMI), physical activity levels, muscle mass, and handgrip strength compared to non-sarcopenic patients, with only IGF-1 levels showing a notable difference between the two RA patient groups.
Diabetes mellitus (DM) is a complex metabolic disorder characterized by chronic hyperglycemia, which derives from either insufficient insulin production [type 1 diabetes mellitus (T1DM)] or both impaired insulin sensitivity along with inadequate insulin production [type 2 diabetes mellitus (T2DM)] and affects millions of people worldwide. In addition to the adverse effects of DM on classical target organs and tissues, skeletal health can also be adversely affected. There is considerable evidence linking DM with osteoporosis.
View Article and Find Full Text PDFIntroduction: Denosumab (Dmab) is widely used for the treatment of post-menopausal osteoporosis. Its discontinuation is sometimes accompanied by multiple vertebral fractures. Romosozumab (Rmab) has not been tested for its ability to prevent the rebound phenomenon.
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- Tooth eruption is crucial for oral development, but various inherited and acquired diseases can disrupt this process, leading to issues like delayed or failed eruption.
- The article reviews how metabolic bone diseases affect various aspects of tooth eruption, including changes in bone metabolism and structure, based on a thorough literature search up to March 2024.
- A multidisciplinary treatment approach is recommended to improve oral health outcomes for patients with these conditions, highlighting the need for personalized evaluations and further research into targeted therapies.