Publications by authors named "S Torrisi"
Article Synopsis
- Chronic low back pain (cLBP) often leads to avoidance or distraction strategies, but the Mind Your Pain (MyP) app shows promise as a mind-body intervention for relief.
- A study with 29 participants assessed the app's effectiveness over 8 weeks, finding significant reductions in pain using the Pain, Enjoyment of Life and General Activity Scale (PEG).
- Results indicated that participants who responded well to MyP displayed increased activation in specific brain areas related to pain, suggesting potential neural biomarkers for cLBP management through mind-body approaches.
Article Synopsis
- Dopamine D3 receptors (D3Rs) play a key role in modulating brain activity, particularly in the hippocampus, which is crucial for memory and learning.
- Blocking or removing D3Rs in mice enhances synaptic activity and improves long-term memory formation by strengthening synaptic connections through the cAMP/PKA signaling pathway.
- In aged mice, D3Rs show a decline in axon terminals but remain stable in dendrites, and blocking these receptors can reverse memory and synaptic deficits, highlighting their potential as a target for treating cognitive decline in older individuals.