Publications by authors named "S Torretta"
Article Synopsis
- - Tumour angiogenesis is crucial for supplying malignant cells with oxygen and nutrients, facilitating their invasion and spread, often resulting in the formation of disorganized and leaky blood vessels due to cytokine activity.
- - Nicotinamide phosphoribosyltransferase (eNAMPT) is elevated in many cancers, acting not only as a necessary enzyme for energy production but also as a pro-inflammatory cytokine that correlates with cancer aggressiveness and prognosis, especially in breast cancer.
- - In triple-negative breast cancer, eNAMPT promotes angiogenesis and metastasis by attracting NG2 pericytes and activating pro-inflammatory signaling, with potential therapeutic effects demonstrated by neutralizing eNAMPT with an antibody, pointing towards new anti-
Article Synopsis
- A study was conducted on 54 adult patients with submandibular stones who underwent a robotic surgery called sialendoscopy-assisted TORSS between January 2019 and June 2023 to evaluate its safety and effectiveness.
- The overall success rate of the procedure was 81.5%, with better outcomes for patients with palpable stones compared to those with non-palpable stones (92.7% vs. 46.2%).
- Results indicated that stone characteristics such as size and location are important for predicting surgical success, emphasizing the need for careful pre-operative planning to select appropriate candidates for the procedure.
Introduction: The European Medicines Agency (EMA) offers scientific advice to support the qualification procedure of novel methodologies, such as preclinical and models, biomarkers, and pharmacometric methods, thereby endorsing their acceptability in medicine research and development (R&D). This aspect is particularly relevant to overcome the scarcity of data and the lack of validated endpoints and biomarkers in research fields characterized by small samples, such as pediatrics.
Aim: This study aimed to analyze the potential pediatric interest in methodologies qualified as "novel methodologies for medicine development" by the EMA.
Dysfunction of the masseter muscle may cause pathological kinking of the parotid duct leading to parotitis; MR sialography is a non-invasive radiological examination that allows to evaluate dynamically the ductal system of the parotid glands. In the present study we aimed to assess the relationships between Stensen's duct and masseter muscle and their implications in the aetiopathogenesis of recurrent parotitis secondary to masseter muscle dysfunction. Forty-one patients with recurrent unilateral parotitis and nine with bilateral recurrent parotitis, all with a clinical suspicious of masseter muscle hypertrophy due to bruxism were enrolled.
View Article and Find Full Text PDFPurpose Of Review: We aimed to reach an Italian multidisciplinary consensus on some crucial aspects of treatment decision making in CRSwNP, following 2 years of clinical experience in order to support specialists in the management of CRSwNP in clinical practice. We addressed issues relating to therapeutic decision-making and shared criteria for the treatment choice, as well as appropriate timing and criteria for evaluating treatment response, and highlighted the need for repeated multidisciplinary assessments.
Recent Findings: A national survey has been conducted recently to understand how rhinology practice has changed in Italy with the advent of biologics and how this affects patients with uncontrolled, severe CRSwNP.