Golodirsen restores DMD transcript imbalance in Duchenne Muscular Dystrophy patient muscle cells.

Background: Antisense oligonucleotides (AON) represent a promising treatment for Duchenne muscular dystrophy (DMD) carrying out-of-frame deletions, but also show limitations. In a completed clinical trial golodirsen, approved by FDA to induce skipping of DMD gene exon 53 in eligible patients, we demonstrated increase in DMD expression and protein production, albeit with inter-patient variability.

Methods: Here, we investigate further the golodirsen mechanism of action using myotubes derived from MyoD transfected fibroblasts isolated from DMD patients at the baseline of the clinical trial SRP-4053.

Enhancing the light yield of He:CF based gaseous detector.

The CYGNO experiment aims to build a large ( m ) directional detector for rare event searches, such as nuclear recoils (NRs) induced by dark matter (DM), such as weakly interactive massive particles (WIMPs). The detector concept comprises a time projection chamber (TPC), filled with a He:CF 60/40 scintillating gas mixture at room temperature and atmospheric pressure, equipped with an amplification stage made of a stack of three gas electron multipliers (GEMs) which are coupled to an optical readout. The latter consists in scientific CMOS (sCMOS) cameras and photomultipliers tubes (PMTs).

Correction: Bio-inspired copper complexes with CuS cores: (solvent) effects on oxygen reduction reactions.

Correction for 'Bio-inspired copper complexes with CuS cores: (solvent) effects on oxygen reduction reactions' by Jordan Mangue , , 2024, , 15576-15582, https://doi.org/10.1039/D4DT01629G.

Bio-inspired copper complexes with CuS cores: (solvent) effects on oxygen reduction reactions.

The need for effective alternative energy sources and "green" industrial processes is a more crucial societal topic than ever. In this context, mastering oxygen reduction reactions (ORRs) is a key step to develop fuel cells or to propose alternatives to energy-intensive setups such as the anthraquinone process for hydrogen peroxide production. Achieving this goal using bio-inspired metal complexes based on abundant and non-toxic elements could provide an environmentally friendly option.

Immunotherapy-Associated Atherosclerosis: A Comprehensive Review of Recent Findings and Implications for Future Research.

Purpose Of The Review: Even as immune checkpoint inhibitors (ICIs) have transformed the lifespan of many patients, they may also trigger acceleration of long-term cardiovascular disease. Our review aims to examine the current landscape of research on ICI-mediated atherosclerosis and address key questions regarding its pathogenesis and impact on patient management.

Recent Findings: Preclinical mouse models suggest that T cell dysregulation and proatherogenic cytokine production are key contributors to plaque development after checkpoint inhibition.