Publications by authors named "S Toprak"
From a global perspective, hepatocellular carcinoma (HCC) and hydatid cyst disease are both common; however, the endemic and zoonotic nature of hydatid cysts (due to larvae) makes the simultaneous detection of the two conditions a rare occurrence. In this case report, in a 43-year-old male patient, we aim to draw attention to the potential coexistence of HCC and liver hydatid cysts by presenting a case in which HCC tissue was detected in the cyst wall-removed by emergency surgery due to cyst perforation. Hydatid lesions in the liver may exhibit tumor-like growth characteristics.
View Article and Find Full Text PDFThe selective extraction of lithium from aqueous systems necessitates efficient sorbent materials. Spinel-type lithium manganese oxide ion sieves (LMOs) have been bee recognized for their high performance in this application. However, the elevated market cost of the spinel form (λ-MnO) raises economic concerns, posing challenges to the feasibility of the extraction process.
View Article and Find Full Text PDFArticle Synopsis
- * This study focuses on using electrolytic manganese dioxide (γ-MnO), a cost-effective material, to extract lithium from the Tuzla Geothermal Power Plant in Turkey through a mini-pilot reactor setup.
- * The research demonstrated effective lithium sorption/desorption, achieving up to 230 mg/L of lithium concentration after multiple cycles, while also confirming that the γ-MnO sorbent retains significant efficiency even after reuse.
The Effects of IGF1 and MGF on Neural Stem Cells in Hypoxic Conditions.
Basic Clin Neurosci
May 2024
Article Synopsis
- Ischemic stroke leads to high rates of illness and death globally, with low oxygen levels making neural stem cells (NSC) more susceptible to injury; this study examines the effects of insulin-like growth factor 1 (IGF-I) and mechano growth factor (MGF) on NSCs under low oxygen conditions.
- An in vitro model using rat hippocampal NSCs exposed to varying oxygen levels showed that low oxygen increased specific gene expressions, with IGF-I downregulating hypoxia-inducible factor (HIF1-α) while MGF improved NSC proliferation across all oxygen scenarios.
- Findings suggest that both IGF-I and MGF enhance NSC proliferation and may have potential therapeutic roles in
Background: Bortezomib, dexamethasone and cyclophosphamide (VCd) remains a popular regimen, due to its activity and low toxicity, while bortezomib, lenalidomide and dexamethasone (VRd) is widely used in US and Europe; both are combined with anti-CD38 monoclonal antibodies but VCd and VRd have not been compared directly in adequately powered prospective trials.
Aim: We compared the outcomes of 1216 patients treated with VCd (N = 690) or VRd (N = 526) in a real-world setting.
Results: Patients treated with VCd had more often severe renal dysfunction, ISS-3 disease, hypercalcemia, elevated LDH, anemia, thrombocytopenia, poor performance while VRd-treated were older and received less often autologous transplant but more frequently maintenance but the duration of induction was similar.