Publications by authors named "S Toor"
Genome-wide association study and polygenic score assessment of insulin resistance.
Front Endocrinol (Lausanne)
June 2024
Insulin resistance (IR) and beta cell dysfunction are the major drivers of type 2 diabetes (T2D). Genome-Wide Association Studies (GWAS) on IR have been predominantly conducted in European populations, while Middle Eastern populations remain largely underrepresented. We conducted a GWAS on the indices of IR (HOMA2-IR) and beta cell function (HOMA2-%B) in 6,217 non-diabetic individuals from the Qatar Biobank (QBB; Discovery cohort; n = 2170, Replication cohort; n = 4047) with and without body mass index (BMI) adjustment.
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- * Researchers conducted whole genome sequencing on over 11,000 participants, identifying and replicating several known genetic loci related to T2D, both with and without considering body mass index (BMI).
- * A unique genetic locus specific to the Qatari population was found, and the study suggests that using a mixed ancestry panel for polygenic risk scores was more effective than one based solely on European data.
Aim: To determine whether horizontal fusional vergences are comparable when measured using a prism bar and synoptophore.
Methods: Thirty two participants (18-23 years) had their blur, break, and recovery points measured for convergence and divergence amplitudes using a prism bar (6 m) and synoptophore. All participants had VA of 0.
Background: Nintedanib slows progression of lung function decline in patients with progressive fibrosing (PF) interstitial lung disease (ILD) and was recommended for this indication within the United Kingdom (UK) National Health Service in Scotland in June 2021 and in England, Wales and Northern Ireland in November 2021. To date, there has been no national evaluation of the use of nintedanib for PF-ILD in a real-world setting.
Methods: 26 UK centres were invited to take part in a national service evaluation between 17 November 2021 and 30 September 2022.