Publications by authors named "S Tonner"
Article Synopsis
- Cancer research is hindered by the need for high-quality, resource-intensive data, and this study compares on-site diagnostic cancer data collected during the SYMPLIFY study with existing cancer registry data from England and Wales to evaluate its validity and timeliness.
- Data from over 5,400 participants was analyzed, focusing on the relevance and timeliness of cancer diagnoses made within nine months of enrollment, covering various classifications including ICD-10 codes, morphology, stage, and TNM classification.
- Findings revealed high levels of data completeness (84%-100% for morphology), but lower completeness for overall stage (43%-100%) and TNM stage (74%-83%), with a notable concordance rate
Article Synopsis
- A study was conducted to assess the ability of the LumiraDx™ test to diagnose SARS-CoV-2 and influenza in community healthcare settings, focusing on symptomatic patients during the Omicron variant wave in the UK.
- The study involved 913 individuals, where the test was compared to the standard rtRT-PCR method, revealing that the LumiraDx™ test had an 80.8% sensitivity for SARS-CoV-2 and a 61.5% sensitivity for Influenza A, with high specificity for both.
- The findings suggest that while the LumiraDx™ test is moderately effective for diagnosing SARS-CoV-2, negative results can't fully eliminate the possibility of infection, especially with higher Ct values from rtRT-PCR tests
Background: Resistance to antibiotics is rising and threatens future antibiotic effectiveness. 'Antibiotic targeting' ensures patients who may benefit from antibiotics receive them, while being safely withheld from those who may not. Point-of-care tests may assist with antibiotic targeting by allowing primary care clinicians to establish if symptomatic patients have a viral, bacterial, combined, or no infection.
View Article and Find Full Text PDFEvaluation of the diagnostic accuracy of two point-of-care tests for COVID-19 when used in symptomatic patients in community settings in the UK primary care COVID diagnostic accuracy platform trial (RAPTOR-C19).
PLoS One
July 2023
Background And Objective: Point-of-care lateral flow device antigen testing has been used extensively to identify individuals with active SARS-CoV-2 infection in the community. This study aimed to evaluate the diagnostic accuracy of two point-of-care tests (POCTs) for SARS-CoV-2 in routine community care.
Methods: Adults and children with symptoms consistent with suspected current COVID-19 infection were prospectively recruited from 19 UK general practices and two COVID-19 testing centres between October 2020 and October 2021.
Background: Analysis of circulating tumour DNA could stratify cancer risk in symptomatic patients. We aimed to evaluate the performance of a methylation-based multicancer early detection (MCED) diagnostic test in symptomatic patients referred from primary care.
Methods: We did a multicentre, prospective, observational study at National Health Service (NHS) hospital sites in England and Wales.