Publications by authors named "S Tonge"
Background: In May, 2022, the first global outbreak of mpox (formerly known as monkeypox) occurred. In response, public health agencies in the UK have made smallpox vaccines available to individuals at the highest risk of infection. With mpox cases still being detected globally, novel tools are required to aid with diagnosis, serosurveillance, and the evaluation of immune responses following infection and immunisation with current and new vaccine candidates.
View Article and Find Full Text PDFBackground: The 2022 Monkeypox virus (MPXV) global outbreak boosted development of multiple serological assays to aid understanding of Mpox immunology.
Objectives: The study aimed to assess a multiplexed solid-phase electrochemiluminescence immunoassay (Meso Scale Discovery (MSD)) for simultaneous detection of antibodies against MPXV, including A35, E8 and M1 antigens, along with corresponding Vaccina Virus (VACV) homologues and demonstrate its accuracy in assessing antibody titres post-vaccination and infection.
Methods: Assay performance was assessed for simultaneous detection of antibodies against MPXV and corresponding VACV antigens.
Background: Diphtheria is rare in England because of an effective national immunisation schedule that includes 5 doses of a diphtheria-containing vaccine at 2, 3, 4 months, preschool and adolescent boosters. However, in recent years there has been a notable increase in cases due to Corynebacterium ulcerans among older adults and evidence of endemic transmission of C. diphtheriae (normally associated with travel to endemic countries).
View Article and Find Full Text PDFArticle Synopsis
- Early 2022 saw a spike in monkeypox virus infections in the UK, with over 80,000 global cases primarily among gay and bisexual men, prompting public health agencies to offer the IMVANEX Smallpox vaccination to high-risk individuals.
- Researchers developed various ELISA tests to analyze antibody responses from individuals who received different doses of the Smallpox vaccine and those previously infected with MPXV, finding that antibody levels increased with booster doses.
- The study identified specific poxvirus antigens linked to MPXV infection, revealing similar antibody responses in those infected and vaccinated, paving the way for future vaccine and therapeutic advancements.