Publications by authors named "S Tomori"
Background: Patients with adult T-cell leukemia/lymphoma (ATL) are considered to have worse outcomes after allogeneic hematopoietic stem cell transplantation (allo-HSCT) than patients with other hematological malignancies, owing to high risk of relapse and immunocompromised status. However, no studies have compared transplant outcomes between patients with ATL and those with other hematological malignancies using a large-scale database.
Objectives: To compare transplant outcomes between patients with ATL and those with other leukemias and to identify factors contributing to worse transplant outcomes in ATL patients.
White-Sutton syndrome (WHSUS) is a rare neurodevelopmental disorder caused by heterozygous variants in the POGZ gene. With slightly over 100 reported cases, the diagnosis of WHSUS remains challenging due to its variable and non-specific clinical features. We report a novel case of WHSUS carrying a heterozygous de novo variant in the POGZ gene and with characteristic clinical features including global developmental delay, autism spectrum disorder, generalised myoclonic epilepsy, hypotonia and distinct dysmorphic features.
View Article and Find Full Text PDFIntroduction: Stigmatising attitudes towards mentally ill people are present among healthcare professionals. The aim of the study was to evaluate medical students' attitudes in five medical schools from Albania, Bulgaria, Moldova, Romania and Serbia and to determine if psychiatry clerkship improves these attitudes.
Methods: In the first stage, the study included students from the first and final years of medical school; in the second stage, only final-year students were included; The Mental Illness Clinicians' Attitude Scale (MICA-2) and the Attribution Questionnaire (AQ-9) were used in this study.
Article Synopsis
- - Bioelectrical impedance analysis (BIA) is a noninvasive method for assessing body composition and fluid status, particularly useful in pediatric patients with nephrotic syndrome, where albumin leaks into urine disrupt blood volume.
- - A case study of a 6-year-old with nephrotic syndrome showed a significant negative correlation between serum albumin levels and the extracellular water/total body water ratio (r=-0.72, P<0.04) during treatment with prednisolone.
- - The findings suggest that BIA could reliably predict serum albumin levels noninvasively, potentially minimizing the need for frequent blood tests in children, though further research is necessary for validation.
Article Synopsis
- Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is the main treatment for adult T-cell leukemia/lymphoma (ATL) and is influenced by individual human leukocyte antigens (HLAs).
- A study analyzed data from 829 ATL patients who received transplants, identifying HLA-B62 as linked to lower mortality risk and HLA-B60 with higher mortality risk after transplantation.
- The findings suggest that specific HLAs can help predict treatment outcomes for ATL patients undergoing allo-HSCT, with potential implications for patient management.