Publications by authors named "S Tomida"
Article Synopsis
- - Emerging research suggests that reduced contractility in aortic smooth muscle cells could play a role in the development of aortic dissection, based on detailed studies of familial thoracic aortic conditions.
- - Unlike the well-studied L-type calcium channels, recent findings indicate that T-type voltage-gated calcium channels may be more closely linked to the impaired contraction in vascular smooth muscle.
- - The review explores various aspects of T-type calcium channels, including their structure, function, and how their decreased activity may lead to less effective muscle contraction, while also discussing the use of multi-omic techniques in this research.
Incontinence-associated dermatitis (IAD) is one of the most serious complications in older people with incontinence. Controlling urine property in absorbent pads could be effective for preventing IAD caused by bacterial urine. However, no animal model has been established to evaluate their effectiveness.
View Article and Find Full Text PDFThe prospective cohort study in a large Japanese population suggested that metabolic phenotypes are important risk factors for total and some site-specific cancers in Japanese adults. Moreover, the risk of each site-specific cancer may differ according to metabolic phenotypes.
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- Idiopathic multicentric Castleman disease (iMCD) is a subtype of Castleman disease that is not linked to KSHV/HHV8 and is categorized into three types: iMCD-IPL, iMCD-TAFRO, and iMCD-NOS.
- The primary treatment is IL-6 inhibitors, yet patients with iMCD-TAFRO and NOS often show resistance, indicating the influence of other cytokines in their pathology.
- A transcriptome analysis revealed increased expression of various cytokine-related genes in iMCD-TAFRO/NOS, suggesting enhanced inflammatory signaling pathways, particularly the JAK-STAT and MAPK pathways, contributing to a potential cytokine storm.
Imatinib may be a useful targeted agent for patients with advanced gastric adenocarcinoma who have KIT mutations.
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