Publications by authors named "S Tomarev"
Information processing and storage in the brain rely on AMPA-receptors (AMPARs) and their context-dependent dynamics in synapses and extra-synaptic sites. We found that distribution and dynamics of AMPARs in the plasma membrane are controlled by Noelins, a three-member family of conserved secreted proteins expressed throughout the brain in a cell-type-specific manner. Noelin tetramers tightly assemble with the extracellular domains of AMPARs and interconnect them in a network-like configuration with a variety of secreted and membrane-anchored proteins including Neurexin1, Neuritin1, and Seizure 6-like.
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- - The regulation of energy balance involves complex interactions between central and peripheral mechanisms that detect energy and nutrient levels, with key cellular players like hypothalamic AMPK responsible for controlling feeding, energy use, and glucose balance.
- - Recent findings highlight the significant influence of traditional senses, particularly olfaction, on energy metabolism, demonstrating that our sense of smell is crucial for food selection and impacts thermogenesis in brown adipose tissue.
- - The review focuses on how olfactory inputs not only affect feeding behaviors but also play a role in regulating overall energy expenditure and metabolism, indicating that our sense of smell has a bidirectional effect on energy balance.
Background And Aims: Olfactomedin 2 (OLFM2; also known as noelin 2) is a pleiotropic protein that plays a major role in olfaction and Olfm2 null mice exhibit reduced olfactory sensitivity, as well as abnormal motor coordination and anxiety-related behavior. Here, we investigated the possible metabolic role of OLFM2.
Methods: Olfm2 null mice were metabolically phenotyped.
miRNA are short non-coding RNA responsible for the knockdown of proteins through their targeting and silencing of complimentary mRNA sequences. The miRNA landscape of a cell thus affects the levels of its proteins and has significant consequences to its health. Deviations in this miRNA landscape have been implicated in a variety of neurodegenerative diseases and have also garnered interest as targets for treatment.
View Article and Find Full Text PDFThe purpose of this study was to characterize the miRNA profile of purified retinal ganglion cells (RGC) from healthy and diseased rat retina. Diseased retina includes those after a traumatic optic nerve crush (ONC), and after ocular hypertension/glaucoma. Rats were separated into four groups: healthy/intact, 7 days after laser-induced ocular hypertension, 2 days after traumatic ONC, and 7 days after ONC.
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