A comparative uptake study of serotonin, dopamine, and norepinephrine by platelets of acute schizophrenic patients.

Active uptake of serotonin, dopamine, and norepinephrine by blood platelets of 22 acute schizophrenic patients and 15 normal control subjects was studied over a 6-week period. The Brief Psychiatric Rating Scale (BPRS) was used to evaluate the subjects' mental state over this period. Serotonin uptake by platelets of the schizophrenic group was 40% lower than that by platelets of the control group (p less than 0.

Serotonin uptake by blood platelets of acute schizophrenic patients.

Active uptake of serotonin by blood platelets of acute schizophrenic patients has been compared to that of a control group. Preliminary results presented in this article indicate that the uptake of the schizophrenic patients was about 40% lower than that of controls. Patients were followed over a period of 5 weeks with no significant change in uptake.