Publications by authors named "S Timsit"
Background: Health disparities along the rural-urban spectrum are a growing concern. The objective of this study was to determine whether in France, clinical profile, care and outcome after ischemic stroke differed between patients affiliated to the statutory health insurance system dedicated to the agricultural economic sector (i.e.
View Article and Find Full Text PDFBackground And Purpose: Mechanical Thrombectomy (MT) has recently become the standard of care for anterior circulation stroke with large vessel occlusion, but predictive factors of successful MT are still not clearly defined. To tailor treatment individually for each patient, the aim of this study was to evaluate the performances of Machine Learning to predict clinical outcome (mRS) at 3 months after MT.
Material And Methods: From the ETIS French prospective multicenter registry, data from patients who underwent MT for anterior circulation stroke with large vessel occlusion between January 2018 and December 2020 were extracted.
Article Synopsis
- The study analyzed stroke trends in patients under 60 in Brest from 2008 to 2018, concluding that despite a general decrease in incidence among older adults, young people experienced a rising trend in ischemic strokes.
- Among the young demographic, significant risk factors included smoking, hypertension, high-alcohol intake, and dyslipidemia.
- The diagnostic approach predominantly included brain imaging and cardiac monitoring, with a notable portion of ischemic strokes being classified as cryptogenic.
Metastatic non-small-cell lung cancer (NSCLC) displays various molecular alterations in the RAS-MAPK pathway. In particular, NSCLCs show high rates of targetable gene fusion in ALK, RET, ROS1, NRG1 and NTRK, or MET exon 14 skipping. Rapid and accurate detection of gene fusion in EGFR/KRAS/BRAF mutations is important for treatment selection especially for first-line indications.
View Article and Find Full Text PDFArticle Synopsis
- The study analyzed 166 patients with acute neurological symptoms linked to anti-GQ1b antibodies, revealing frequent symptoms like areflexia, sensory issues, and muscle weakness.
- The majority of patients were treated with intravenous immunoglobulins, leading to complete neurological recovery for 69% at the one-year mark, although 15% experienced relapses.
- Key predictors for incomplete recovery included age over 70, initial ICU admission, and absence of anti-GQ1b antibodies; no predictors for relapse were identified.