Efficacy and Safety of Oral Neomycin for the Decolonization of Carbapenem-Resistant : An Open-Label Randomized Controlled Trial.

Background: Patients with carbapenem-resistant (CRE) in the gastrointestinal (GI) tract are at risk for subsequent infections and transmission, necessitating contact precautions. Neomycin has shown in vitro activity against CRE in 66-85% of isolates. This study evaluated the efficacy and safety of neomycin for CRE decolonization.

The risk of pig and chicken farming for carriage and transmission of containing extended-spectrum beta-lactamase (ESBL) and mobile colistin resistance () genes in Thailand.

South-East Asian countries report a high prevalence of extended-spectrum cephalosporin- (ESC-) and colistin-resistant (Col-R-). However, there are still few studies describing the molecular mechanisms and transmission dynamics of ESC-R- and, especially, Col-R-. This study aimed to evaluate the prevalence and transmission dynamics of containing extended spectrum beta-lactamases (ESBL) and mobile colistin resistance () genes using a 'One Health' design in Thailand.

Surveillance of Antimicrobial Resistance Phenotypes in Selected Communities in Thailand.

Integrated surveillance of antimicrobial resistance (AMR) using the approach that includes humans, animals, food, and the environment has been recommended by responsible international organizations. The objective of this study was to determine the prevalence of AMR phenotypes in and species isolated from humans, pigs, chickens, and wild rodents in five communities in northern Thailand. Rectal swabs from 269 pigs and 318 chickens; intestinal contents of 196 wild rodents; and stool samples from 69 pig farmers, 155 chicken farmers, and 61 non-farmers were cultured for and species, which were then tested for resistance to ceftriaxone, colistin, and meropenem.

Feasibility, Challenges, and Benefits of Global Antimicrobial Resistance Surveillance System Implementation: Results from a Multicenter Quasi-Experimental Study.

The Global Antimicrobial Resistance Surveillance System (GLASS) is one of the pillars of the global action plan on antimicrobial resistance launched by the World Health Organization in 2015. This study was conducted to determine the feasibility and benefits of GLASS as a component of antimicrobial stewardship strategies in three provincial hospitals in Thailand. Data on the types of bacteria isolated and their antibiotic susceptibility during January-December 2019 and January-April 2020 were retrieved from the microbiology laboratory of each participating hospital.

A One Health approach to assessing occupational exposure to antimicrobial resistance in Thailand: The FarmResist project.

This Southeast Asia-Europe research project will use a One Health approach to identify the major parameters responsible for the presence of animal-associated antimicrobial resistant bacteria in animal production facilities in Thailand and the risk of their transmission from animals to humans. We will focus on traditional, small, extensive pig and poultry farms where information on antibiotic use is scarce and animals live in close contact with humans. This cross-sectional study will be based on the epidemiological analysis of the antimicrobial resistance (AMR) present in fecal samples from animals and humans.