Publications by authors named "S Thota"
Carbon dots from alternative renewable carbon sources are emerging as alternatives to metal-based quantum dots. These nature-derived carbon dots exhibit excellent optical and fluorescent properties, which enable their use in several applications, including bioimaging. This work presents a facile and green approach to synthesizing highly fluorescent carbon dots from groundnut shells (GNS), an abundantly available agricultural residue.
View Article and Find Full Text PDFEvolution of tunable energy bandgap and magnetic anisotropy in Mn substituted ferrimagnetic nickel-chromates.
J Phys Condens Matter
December 2024
Article Synopsis
- The study investigates how substituting manganese (Mn) at B sites affects the structural, electronic, magnetic, and optical properties of nickel chromate spinel (NiCrO), revealing no major structural distortion but changes in bond angles and lengths as Mn content varies.
- Electronic structure analysis shows that nickel is divalent while chromium and manganese remain trivalent, with these configurations influencing the material's semiconducting nature and direct bandgap that ranges from 1.16 to 2.40 eV.
- All compositions exhibit ferrimagnetic ordering below the Néel temperature, with magnetic properties improving as Mn is added; however, the anisotropy shows a decreasing trend which is attributed to
Article Synopsis
- DDoS attacks are serious threats in cloud computing that disrupt services, causing financial and reputational harm, making their detection essential.
- The study presents a deep learning-based intrusion detection system that includes data pre-processing, balancing with CGAN, and classification using a stacked sparse denoising autoencoder optimized by a hybrid algorithm.
- Experiments using the CICDDoS2019 dataset show that the proposed method significantly outperforms existing techniques in accurately detecting DDoS attacks, emphasizing the importance of advanced deep learning in cybersecurity.
Article Synopsis
- Cancer patients, particularly those with melanoma and non-small cell lung cancer (NSCLC), show higher rates of clonal hematopoiesis, which could influence their treatment and outcomes.
- The study examines how immune checkpoint blockade (ICB) therapy impacts the hematopoietic clonal architecture and whether changes in clonal expansion affect hematopoietic health in these patients.
- Findings suggest that mutations within the hematopoietic system increase with extended ICB therapy, raising questions about the potential for clonal hematopoiesis to predict therapy responses and the long-term risks of developing myeloid malignancies.
Engineered FHA domains can bind to a variety of Phosphothreonine-containing peptides.
Protein Eng Des Sel
January 2024
Antibodies play a crucial role in monitoring post-translational modifications, like phosphorylation, which regulates protein activity and location; however, commercial polyclonal and monoclonal antibodies have limitations in renewability and engineering compared to recombinant affinity reagents. A scaffold based on the Forkhead-associated domain (FHA) has potential as a selective affinity reagent for this post-translational modification. Engineered FHA domains, termed phosphothreonine-binding domains (pTBDs), with limited cross-reactivity were isolated from an M13 bacteriophage display library by affinity selection with phosphopeptides corresponding to human mTOR, Chk2, 53BP1, and Akt1 proteins.
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