Publications by authors named "S Thietart"
Background: Hip fracture is common and associated with high morbidity and mortality rates. Selective serotonin reuptake inhibitors (SSRIs) influence platelet hemostasis and might result in abnormal bleeding. This study aims to determine whether the use of SSRIs in older patients undergoing hip fracture surgery is associated with the risk of perioperative red blood cell (RBC) transfusion.
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- Chronic high cholesterol levels lead to systemic immune responses that accelerate atherosclerosis, but the impact of alternating high-fat diets (HFD) had not been well studied.
- Researchers used a mouse model to compare the effects of an alternating HFD versus a continuous HFD on atherosclerosis progression, finding that the alternating diet significantly worsened the condition.
- The study revealed that this worsening was linked to IL-1β production, which triggered inflammatory responses and increased neutrophil levels that contributed to plaque formation and exacerbated atherosclerosis, suggesting that targeting these pathways could reverse the effects.
Innate immune response in acute critical illness: a narrative review.
Ann Intensive Care
September 2024
Background: Activation of innate immunity is a first line of host defense during acute critical illness (ACI) that aims to contain injury and avoid tissue damages. Aberrant activation of innate immunity may also participate in the occurrence of organ failures during critical illness. This review aims to provide a narrative overview of recent advances in the field of innate immunity in critical illness, and to consider future potential therapeutic strategies.
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- Hip fractures primarily impact older adults, leading to increased health complications and risks, prompting a review of non-steroidal anti-inflammatory drugs (NSAIDs) during their surgical recovery.
- The systematic review followed PRISMA guidelines, analyzing various studies on NSAIDs' effectiveness and safety in post-operative outcomes like pain control and complications after hip fracture surgery.
- Although some studies supported NSAIDs for pain management, findings on safety were inconsistent, indicating a need for more research to clarify the overall benefits and risks of using NSAIDs in these patients.*