Publications by authors named "S Theodoropoulou"
Article Synopsis
- * Research indicates that levels of IRAK-M decrease with age and oxidative stress, with genetic variants linked to a higher risk of developing AMD.
- * Restoring IRAK-M in RPE cells shows promise in protecting against oxidative damage and retinal degeneration, indicating it could be a potential therapeutic avenue for AMD.
The present study concerns the preparation of hybrid nanostructures composed of carbon dots (CDs) synthesized in our lab and a double-hydrophilic poly(2-dimethylaminoethyl methacrylate--oligo(ethylene glycol) methyl ether methacrylate) (P(DMAEMA--OEGMA)) random polymer through electrostatic interactions between the negatively charged CDs and the positively charged DMAEMA segments of the polymer. The synthesis of P(DMAEMA--OEGMA) polymer was conducted through RAFT polymerization. Furthermore, the polymer was converted into a strong cationic random polyelectrolyte through quaternization of the amine groups of DMAEMA segments with methyl iodide (CHI), and it was subsequently utilized for the complexation with the carbon dots.
View Article and Find Full Text PDFUnchecked, chronic inflammation is a constitutive component of age-related diseases, including age-related macular degeneration (AMD). Here we identified interleukin-1 receptor-associated kinase (IRAK)-M as a key immunoregulator in retinal pigment epithelium (RPE) that declines with age. Rare genetic variants of IRAK-M increased the likelihood of AMD.
View Article and Find Full Text PDFBackground/objectives: Timely assessment and treatment of patients with neovascular AMD (nAMD) are crucial to preservation of vision. Loss to follow up (LTFU) in these patients is a problem but this has not been systematically investigated.
Subjects/methods: A retrospective review of electronic medical records of patients with nAMD first treated with anti-VEGF therapy from 1st Jan 2014 to 31st Dec 2018, was conducted in January 2021.