Publications by authors named "S Terzoli"
γδ T cells provide rapid cellular immunity against pathogens. Here, we conducted matched single-cell RNA-sequencing and γδ-TCR-sequencing to delineate the molecular changes in γδ T cells during a longitudinal study following mRNA SARS-CoV-2 vaccination. While the first dose of vaccine primes Vδ2 T cells, it is the second administration that significantly boosts their immune response.
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- Haploidentical hematopoietic stem cell transplantation (h-HSCT) is a treatment for blood cancers that relies on effective immune reconstitution (IR) to prevent severe infections like Human Cytomegalovirus (HCMV).
- The study reveals that specific types of Natural Killer (NK) cells, called KIR NK cells, significantly contribute to controlling HCMV due to their early recovery and strong antiviral properties.
- Maintaining high levels of KIR NK cells post-transplant can serve as a predictor for HCMV infection risk and could lead to improved treatments by boosting these immune cells in donor lymphocyte infusions.
Article Synopsis
- Higher frequencies of mucosal-associated invariant T (MAIT) cells are linked to a better immune response to the mRNA SARS-CoV-2 vaccine, with the hypothesis that TNF produced by these cells aids B cell activation after immunization.
- A study analyzed peripheral blood mononuclear cells (PBMCs) from vaccinated adults at various time intervals following the Pfizer-BioNTech vaccine to explore the effects of repeated vaccinations on MAIT cells.
- Results show that MAIT cells produce TNF in response to the vaccine, which boosts their proliferation and enhances anti-SARS-CoV-2 antibody production, especially activating memory B cells essential for long-term immunity.
Introduction: Adult-type diffuse gliomas are malignant primary brain tumors characterized by very poor prognosis. Dendritic cells (DCs) are key in priming antitumor effector functions in cancer, but their role in gliomas remains poorly understood.
Methods: In this study, we characterized tumor-infiltrating DCs (TIDCs) in adult patients with newly diagnosed diffuse gliomas by using multi-parametric flow cytometry and single-cell RNA sequencing.
Monocytes are critical cells of the immune system but their role as effectors is relatively poorly understood, as they have long been considered only as precursors of tissue macrophages or dendritic cells. Moreover, it is known that this cell type is heterogeneous, but our understanding of this aspect is limited to the broad classification in classical/intermediate/non-classical monocytes, commonly based on their expression of only two markers, i.e.
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